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Creatine's Brain Effects: https://www.youtube.com/watch?v=Iko8ytFELCE

0:00 - Introduction
1:10 - A Muscle-centric Dose may be Insufficient
5:37 - Stress, Sleep, and Creatine
9:50 - Main Points

References
[1] Dechent P, Pouwels PJ, Wilken B, Hanefeld F, Frahm J. Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. Am J Physiol. 1999;277(3):R698-R704. doi:10.1152/ajpregu.1999.277.3.R698

[2] Pan JW, Takahashi K. Cerebral energetic effects of creatine supplementation in humans. Am J Physiol Regul Integr Comp Physiol. 2007;292(4):R1745-R1750. doi:10.1152/ajpregu.00717.2006

[3] Lyoo IK, Kong SW, Sung SM, et al. Multinuclear magnetic resonance spectroscopy of high-energy phosphate metabolites in human brain following oral supplementation of creatine-monohydrate. Psychiatry Res Neuroimaging. 2003;123(2):87-100. doi:10.1016/S0925-4927(03)00046-5

[4] Kondo DG, Forrest LN, Shi X, et al. Creatine target engagement with brain bioenergetics: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression. Amino Acids. 2016;48(8):1941-1954. doi:10.1007/s00726-016-2194-3

[5] Atassi N, Ratai EM, Greenblatt DJ, et al. A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2010;11(6):508-513. doi:10.3109/17482961003797130

[6] Gordji-Nejad A, Matusch A, Kleedörfer S, et al. Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. Sci Rep. 2024;14(1):4937. Published 2024 Feb 28. doi:10.1038/s41598-024-54249-9

[7] McMorris T, Harris RC, Swain J, et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006;185(1):93-103. doi:10.1007/s00213-005-0269-z

[8] Cook CJ, Crewther BT, Kilduff LP, Drawer S, Gaviglio CM. Skill execution and sleep deprivation: effects of acute caffeine or creatine supplementation - a randomized placebo-controlled trial. J Int Soc Sports Nutr. 2011;8:2. Published 2011 Feb 16. doi:10.1186/1550-2783-8-2

[9] Smith AN, Choi IY, Lee P, et al. Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition. Alzheimers Dement (N Y). 2025;11(2):e70101. Published 2025 May 19. doi:10.1002/trc2.70101

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