The Surprisingly Negative Findings around Blueberries

Physionic

Jun 29, 2026

Episode description

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0:00 - Introduction
0:50 - Anthocyanins: My Heart!
2:53 - Pass me the Blueberries
5:25 - Pass on the Blueberries?
9:23 - Alternatives?

References*
*Full Funding/Conflicts are provided in the free article (found in email list and Physionic Community Article Library)
[Study 849] Cassidy A, Mukamal KJ, Liu L, et al. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation. 2013;127(2):188-196. doi:10.1161/CIRCULATIONAHA.112.122408

[Study 850] Mink PJ, Scrafford CG, Barraj LM, et al. Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am J Clin Nutr. 2007;85(3):895-909. doi:10.1093/ajcn/85.3.895

[Study 851] Bondonno NP, Liu YL, Zheng Y, et al. Change in habitual intakes of flavonoid-rich foods and mortality in US males and females. BMC Med. 2023;21(1):181. Published 2023 May 12. doi:10.1186/s12916-023-02873-z

[Study 852] Curtis PJ, van der Velpen V, Berends L, et al. Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome—results from a 6-month, double-blind, randomized controlled trial. Am J Clin Nutr. 2019;109(6):1535-1545. doi:10.1093/ajcn/nqy380

[Study 853] Stull AJ, Cash KC, Champagne CM, et al. Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: a randomized, double-blind, placebo-controlled clinical trial. Nutrients. 2015;7(6):4107-4123. Published 2015 May 27. doi:10.3390/nu7064107

[Study 854] Woolf EK, Terwoord JD, Litwin NS, et al. Daily blueberry consumption for 12 weeks improves endothelial function in postmenopausal women with above-normal blood pressure through reductions in oxidative stress: a randomized controlled trial. Food Funct. 2023;14(6):2621-2641. Published 2023 Mar 20. doi:10.1039/d3fo00157a

[Study 855] Basu A, Du M, Leyva MJ, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr. 2010;140(9):1582-1587. doi:10.3945/jn.110.124701

[Study 856] Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, et al. Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr. 2013;98(5):1179-1191. doi:10.3945/ajcn.113.066639

[Study 857] Wang Y, Gallegos JL, Haskell-Ramsay C, Lodge JK. Effects of Blueberry Consumption on Cardiovascular Health in Healthy Adults: A Cross-Over Randomised Controlled Trial. Nutrients. 2022;14(13):2562. Published 2022 Jun 21. doi:10.3390/nu14132562

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Reassess blueberry consumption for blood pressure and lipid impact

Multiple randomized controlled trials show that blueberry consumption has no impact on blood pressure, insulin resistance, or blood lipids like cholesterol.

Reassess blueberry consumption's impact on heart disease mortality

After adjusting for lifestyle factors, increased blueberry consumption does not correlate with a reduced risk of cardiovascular disease mortality.

Incorporate elderberries, chokeberries, and blackcurrants for anthocyanin boost

Besides blueberries, other potent sources of anthocyanins include elderberries, chokeberries, blackcurrants, red cabbage, and purple sweet potatoes.

Prioritize anthocyanin intake from diverse sources

The main lesson is to aim for general anthocyanin consumption from various sources rather than focusing specifically on blueberries.

Consume one cup of blueberries daily for optimal health benefits

Only consuming one cup of blueberries per day, not half a cup, led to a meaningful rise of their beneficial metabolites in the blood.

Consume blueberries to enhance blood vessel function

Consuming blueberries reliably improves flow-mediated dilation, a key measure of how well blood vessels can relax and adapt.

Increase anthocyanin intake to lower cardiovascular disease risk

Multiple long-term studies indicate that consuming more anthocyanins, the compounds found in blueberries, is linked to a reduced risk of cardiovascular disease.

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