Dr. Saladino: Avoid Coffee - It’s Full of Defense Chemicals!

Physionic

May 14, 2025

Episode description

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0:00 - Introduction
0:50 - Why Coffee is Harmful
4:15 - The Anti-Saladonian Plant Hypothesis
5:14 - Caffeine's Harm
9:06 - Decaf Coffee - Better?
10:51 - The Science behind Coffee
12:08 - Main Points

Original video: https://www.youtube.com/watch?v=pNwpPIftL-4

References
[A] Yamagata K. Do Coffee Polyphenols Have a Preventive Action on Metabolic Syndrome Associated Endothelial Dysfunctions? An Assessment of the Current Evidence. Antioxidants (Basel). 2018;7(2):26. Published 2018 Feb 4. doi:10.3390/antiox7020026

[B] Huang J, Xie M, He L, Song X, Cao T. Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems. Front Pharmacol. 2023;14:1218015. Published 2023 Sep 13. doi:10.3389/fphar.2023.1218015

[C] Gardiner C, Weakley J, Burke LM, et al. The effect of caffeine on subsequent sleep: A systematic review and meta-analysis. Sleep Med Rev. 2023;69:101764. doi:10.1016/j.smrv.2023.101764

[D] Liew SC, Aung T. Sleep deprivation and its association with diseases- a review. Sleep Med. 2021;77:192-204. doi:10.1016/j.sleep.2020.07.048

[E] Zhang F, Zhong R, Li S, et al. Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline. Alzheimers Dement. 2019;15(4):590-597. doi:10.1016/j.jalz.2018.12.004

[F] Kanclerska J, Szymańska-Chabowska A, Poręba R, et al. A Systematic Review of Publications on the Associations Between Sleep Architecture and Arterial Hypertension. Med Sci Monit. 2023;29:e941066. Published 2023 Sep 4. doi:10.12659/MSM.941066

[G] Kim Y, Je Y, Giovannucci E. Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers. Eur J Epidemiol. 2019;34(8):731-752. doi:10.1007/s10654-019-00524-3

[H] Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23(5):921-928. doi:10.1097/01.hjh.0000166828.94699.1d

[I] Ungvari Z, Kunutsor SK. Coffee consumption and cardiometabolic health: a comprehensive review of the evidence. Geroscience. 2024;46(6):6473-6510. doi:10.1007/s11357-024-01262-5

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:50 - Why Coffee is Harmful
4:15 - The Anti-Saladonian Plant Hypothesis
5:14 - Caffeine's Harm
9:06 - Decaf Coffee - Better?
10:51 - The Science behind Coffee
12:08 - Main Points

Original video: https://www.youtube.com/watch?v=pNwpPIftL-4

References
[A] Yamagata K. Do Coffee Polyphenols Have a Preventive Action on Metabolic Syndrome Associated Endothelial Dysfunctions? An Assessment of the Current Evidence. Antioxidants (Basel). 2018;7(2):26. Published 2018 Feb 4. doi:10.3390/antiox7020026

[B] Huang J, Xie M, He L, Song X, Cao T. Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems. Front Pharmacol. 2023;14:1218015. Published 2023 Sep 13. doi:10.3389/fphar.2023.1218015

[C] Gardiner C, Weakley J, Burke LM, et al. The effect of caffeine on subsequent sleep: A systematic review and meta-analysis. Sleep Med Rev. 2023;69:101764. doi:10.1016/j.smrv.2023.101764

[D] Liew SC, Aung T. Sleep deprivation and its association with diseases- a review. Sleep Med. 2021;77:192-204. doi:10.1016/j.sleep.2020.07.048

[E] Zhang F, Zhong R, Li S, et al. Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline. Alzheimers Dement. 2019;15(4):590-597. doi:10.1016/j.jalz.2018.12.004

[F] Kanclerska J, Szymańska-Chabowska A, Poręba R, et al. A Systematic Review of Publications on the Associations Between Sleep Architecture and Arterial Hypertension. Med Sci Monit. 2023;29:e941066. Published 2023 Sep 4. doi:10.12659/MSM.941066

[G] Kim Y, Je Y, Giovannucci E. Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers. Eur J Epidemiol. 2019;34(8):731-752. doi:10.1007/s10654-019-00524-3

[H] Noordzij M, Uiterwaal CS, Arends LR, Kok FJ, Grobbee DE, Geleijnse JM. Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials. J Hypertens. 2005;23(5):921-928. doi:10.1097/01.hjh.0000166828.94699.1d

[I] Ungvari Z, Kunutsor SK. Coffee consumption and cardiometabolic health: a comprehensive review of the evidence. Geroscience. 2024;46(6):6473-6510. doi:10.1007/s11357-024-01262-5

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Manage caffeine intake to avoid sleep disruption

The quarter-life of caffeine is 12 hours, meaning 25% of the caffeine from a morning coffee is still affecting your brain's physiology when you go to sleep at night.

Understand coffee's defense chemicals to appreciate its evolution

Coffee beans are seeds containing defense chemicals because plants have evolved to discourage animals from eating them.

Activate antioxidant pathways with coffee's beneficial molecules

Beneficial molecules in coffee, like chlorogenic acid, stimulate a potent antioxidant pathway in our cells called the NRF2 pathway.

Beware mold toxins in decaf coffee for better health

Even if you drink decaf to protect your sleep, many coffees contain mold toxins, which present another health problem.

Drink coffee to lower cardiovascular and all-cause mortality risk

Despite potential negative mechanisms, long-term studies show people who drink coffee have a reduced risk of cardiovascular and all-cause mortality.

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