Exercise shrinks Plaque, but it does more than that…

Physionic

Jan 29, 2025

Episode description

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0:00 - Introduction
1:00 - How does Exercise reduce Plaque in our Arteries?
4:14 - Other Ways Exercise avoids Heart Attack
6:15 - The Clinical Evidence...
8:07 - How to Reverse Plaque - Multiple Factors
9:30 - CAC scores and Plaque Stabilization
11:40 - Take-Aways

References
[Study 392] Chacon D, Fiani B. A Review of Mechanisms on the Beneficial Effect of Exercise on Atherosclerosis. Cureus. 2020;12(11):e11641. Published 2020 Nov 23. doi:10.7759/cureus.11641

Funding/Conflicts: None / No Conflicts of Interest

[Study 393] Aengevaeren VL, Mosterd A, Sharma S, et al. Exercise and Coronary Atherosclerosis: Observations, Explanations, Relevance, and Clinical Management. Circulation. 2020;141(16):1338-1350. doi:10.1161/CIRCULATIONAHA.119.044467

Funding/Conflicts: Non-Profit Funding [Dutch Heart Foundation] / No Conflicts of Interest

[Study 245] Madssen E, Moholdt T, Videm V, Wisløff U, Hegbom K, Wiseth R. Coronary atheroma regression and plaque characteristics assessed by grayscale and radiofrequency intravascular ultrasound after aerobic exercise. Am J Cardiol. 2014;114(10):1504-1511. doi:10.1016/j.amjcard.2014.08.012

Public and Private Funding - Central Norway Regional Health Authority, Norwegian University of Science and Technology

[Study 246] Vesterbekkmo EK, Aksetøy IA, Follestad T, et al. High-intensity interval training induces beneficial effects on coronary atheromatous plaques: a randomized trial. Eur J Prev Cardiol. 2023;30(5):384-392. doi:10.1093/eurjpc/zwac309

Public and Private Funding - Central Norway Regional Health Authority, Norwegian University of Science and Technology

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Mindsip insights from this episode:

Promote new blood vessel growth through exercise for natural bypass

Exercise can promote the growth of new blood vessels that create a natural, non-surgical bypass around an arterial occlusion.

#blood-flow

#exercise

Understand safer plaque composition in athletes

Studies on athletes suggest that while they may have plaque, it tends to be more calcified and less of the volatile 'mixed' type, which is considered the most dangerous.

#exercise

#plaque

Reduce arterial plaque through regular exercise

Exercise appears to reduce plaque by helping immune cells migrate out of the atheroma, reducing lipoprotein uptake, and promoting reverse cholesterol transport via HDL.

#exercise

#plaque

Utilize exercise for cardiac preconditioning and heart resilience

Exercise can improve heart health through a process called cardiac preconditioning, which is akin to giving the heart mini heart attacks to make it more resilient.

#exercise

#heart

Combine exercise with reduced apob lipoproteins and lower blood pressure for plaque reduction

The plaque-reducing effects of exercise are most potent when paired with reducing the number of apob-containing lipoproteins and lowering blood pressure.

#blood-pressure

#exercise

Aim to burn 2,200 calories weekly to reverse plaque

A target to aim for to potentially reverse plaque is burning 2,200 calories per week, which is equivalent to about five to six hours of exercise.

#exercise

#plaque

Stabilize dangerous plaque through regular exercise

Instead of just removing plaque, exercise can also stabilize it by thickening its fibrous cap or increasing its calcification, making it less likely to rupture.