Hard to Believe Dementia Effects Found

Brad Stanfield

Jul 7, 2025

Episode description

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Here are the links to the research papers referenced in the video:
https://www.nature.com/articles/s41591-024-03340-9
https://www.who.int/news-room/fact-sheets/detail/dementia
https://pmc.ncbi.nlm.nih.gov/articles/PMC8659196/
https://www.ncbi.nlm.nih.gov/books/NBK430817/
https://www.mdpi.com/2813-2564/4/1/2
https://www.ncbi.nlm.nih.gov/books/NBK551568/
https://www.mdpi.com/2813-2564/4/1/2
https://www.ncbi.nlm.nih.gov/books/NBK576405/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11351143/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4878312/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4877513/
https://pubmed.ncbi.nlm.nih.gov/32562683/
https://jamanetwork.com/journals/jamaneurology/article-abstract/2831976
https://pmc.ncbi.nlm.nih.gov/articles/PMC10363181/
https://journals.sagepub.com/doi/10.1177/25424823251342182
https://pmc.ncbi.nlm.nih.gov/articles/PMC12125485/
https://pubmed.ncbi.nlm.nih.gov/39780249/
https://www.ncbi.nlm.nih.gov/books/NBK576405/
https://cardiab.biomedcentral.com/articles/10.1186/s12933-020-01071-y
https://pmc.ncbi.nlm.nih.gov/articles/PMC7710304/

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

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Mindsip insights from this episode:

Reduce dementia risk with SGLT2 inhibitors

The same nine-year study found that patients using SGLT2 inhibitors had a 43% lower risk of dementia compared to those on other treatments.

#dementia

#SGLT2

Address insulin resistance to combat Alzheimer's disease

Alzheimer's disease and type 2 diabetes share a key mechanism where cells lose the ability to respond properly to insulin, which regulates blood sugar.

#Alzheimer's

#insulin

Prepare for high dementia risk in Americans over 55

A recent analysis projects that up to 42% of Americans over the age of 55 will eventually develop dementia, a much higher estimate than previously thought.

#dementia

#risk

Reduce dementia risk with GLP-1 drugs for type 2 diabetes

A recent nine-year study of patients with type 2 diabetes found that those taking a GLP-1 agonist had a 33% lower risk of developing dementia.

#dementia

#GLP1

Utilize GLP-1 drugs to combat brain inflammation and oxidative stress

GLP-1 agonists like Ozempic can cross the blood-brain barrier to directly provide an anti-inflammatory effect and combat oxidative stress within the brain.

#GLP1

#oxidative-stress

Monitor Alzheimer's trials for semaglutide outcomes by 2026

Large clinical trials called Evoke and Evoke plus are currently testing semaglutide on people with early-stage Alzheimer's, with results expected in 2026.

#Alzheimer's

#GLP1

Block glucose reabsorption with SGLT2 inhibitors to eliminate excess sugar

SGLT2 inhibitors work by blocking the kidneys from reabsorbing glucose, causing excess sugar to be filtered out and removed from the body through urine.