NMN & NAD for Anti-Aging Just Changed

Brad Stanfield

Dec 27, 2025

Episode description

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Timestamps:
00:00 Discovering the Role of SIR2 and NAD in Longevity
01:14 Correlation Between NAD Levels and Aging
02:05 The Hype and Reality of NMN and NR Supplements
03:46 David Sinclair's Advocacy for NMN Supplements
04:21 The Interventions Testing Program's Findings on NR
05:41 Questioning the Theory of NAD Levels Decline with Age
05:59 The Effect of NR Supplements on Long COVID
07:47 Are TMG Supplements the Real Reason for Benefits?
08:55 Conclusion and Key Takeaways

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Here are the links to the research papers referenced in the video:
https://www.science.org/doi/10.1126/science.289.5487.2126
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357
https://www.science.org/doi/10.1126/science.aaf2693
https://pmc.ncbi.nlm.nih.gov/articles/PMC8135004/
https://www.nature.com/articles/s43587-022-00174-3
https://www.sciencedirect.com/science/article/pii/S258953702500567X
https://pubmed.ncbi.nlm.nih.gov/39514262/
https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00464-y

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

Mindsip insights from this episode:

Address reproducibility crisis in scientific research

A dirty secret in scientific research is the "reproducibility crisis," where exciting initial discoveries often cannot be repeated by other researchers.

#research

Reevaluate NAD decline theory with exercise in older adults

The theory that NAD levels decline with age has been called into question, as muscle biopsies show exercising older adults have similar NAD levels to younger adults.

#aging

#NAD

Reject NR supplements for long Covid relief

In a recent study on long Covid, NR supplements raised NAD levels but provided no functional improvements or symptom relief, serving as a "nail in the coffin" for the supplement.

#COVID-19

#supplement

Investigate TMG's role in enhancing NMN benefits

Anecdotal benefits from NMN or NR might actually come from TMG, a supplement often taken alongside them that has clinical evidence for improving muscle performance.

#supplement

#TMG

Question NMN hype without human clinical trial evidence

At the time David Sinclair was promoting NMN on popular podcasts, there was not a single human clinical trial on its claimed benefits.

#clinical-trial

#supplement

Challenge NR supplements for lifespan benefits based on testing results

The Interventions Testing Program, a multi-lab study, found that while NR supplements raised NAD levels in mice, they failed to increase their lifespan.