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0:00 - Introduction
0:32 - Sweeteners and Declining Brain Health
2:52 - Why I'm Worried...
6:18 - Main Points/Key Takeaways

References
[Study 522] Gonçalves NG, Martinez-Steele E, Lotufo PA, et al. Association Between Consumption of Low-and No-Calorie Artificial Sweeteners and Cognitive Decline: An 8-Year Prospective Study. ​ Neurology. 2025;105:e214023. doi:10.1212/WNL.0000000000214023.

Funding/Conflicts: No Funding / No direct Conflicts of Interest

[A] McGlynn ND, Khan TA, Wang L, et al. Association of Low- and No-Calorie Sweetened Beverages as a Replacement for Sugar-Sweetened Beverages With Body Weight and Cardiometabolic Risk: A Systematic Review and Meta-analysis. JAMA Netw Open. 2022;5(3):e222092. Published 2022 Mar 1. doi:10.1001/jamanetworkopen.2022.2092

[B] Spiers PA, Sabounjian L, Reiner A, Myers DK, Wurtman J, Schomer DL. Aspartame: neuropsychologic and neurophysiologic evaluation of acute and chronic effects. Am J Clin Nutr. 1998;68(3):531-537. doi:10.1093/ajcn/68.3.531

[C] Lapierre KA, Greenblatt DJ, Goddard JE, Harmatz JS, Shader RI. The neuropsychiatric effects of aspartame in normal volunteers. J Clin Pharmacol. 1990;30(5):454-460. doi:10.1002/j.1552-4604.1990.tb03485.x

[D] Lindseth GN, Coolahan SE, Petros TV, Lindseth PD. Neurobehavioral effects of aspartame consumption. Res Nurs Health. 2014;37(3):185-193. doi:10.1002/nur.21595

[E] Sucralose reduced cognitive function vs sucrose: López-Meza MS, Otero-Ojeda G, Estrada JA, Esquivel-Hernández FJ, Contreras I. The impact of nutritive and non-nutritive sweeteners on the central nervous system: preliminary study. Nutr Neurosci. 2022;25(8):1623-1632. doi:10.1080/1028415X.2021.1885239

[F] Maben AL, Smith AP. Sugar, aspartame and mental performance: a preliminary investigation. Hum Psychopharmacol Clin Exp. 1996;11(1):21-23.

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