Linus Pauling: Vindicated by New Evidence?

Physionic

Dec 1, 2025

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomyJOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6HIRE ME FOR CONSULTING: Consulting: https://bit.ly/3dmUl2H Created with BiorenderNutrition Protocol with Vitamin C: https://youtu.be/phg_9Vv22fk?si=n_zBOymDvD8KtCpg0:00 - Introduction0:50 - Using Vitamin C on Cancer3:00 - Why was Vitamin C dismissed in the Past?5:05 - New Evidence...8:34 - Main PointsReferences[Study 547] Sun X, Cai X, Li S, et al. High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy. Cell Rep Med. 2025;6(8):101234.Funding/Conflicts: Public funding: This study was supported by governmental agencies, including the National Natural Science Foundation of China, the Natural Science Foundation of Guangdong Province, the Regional Joint Fund Project of the Basic and Applied Basic Research Foundation of Guangdong Province, and the Science and Technology Projects in Guangzhou; Non-profit funding: No non-profit organization funding was reported; Industry funding: No industry funding was reported, and the authors stated that they have no competing interests or conflicts of interest.[A] Creagan ET, Moertel CG, O'Fallon JR, et al. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med. 1979;301(13):687-690. doi:10.1056/NEJM197909273011303[B] Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ, Ames MM. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med. 1985;312(3):137-141. doi:10.1056/NEJM198501173120301[C] Jameson GS, LeGrand SD, Gordon MS, et al. Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer. Redox Biol. Published online October 25, 2025. doi:10.1016/j.redox.2025.103895[D] Wang F, He MM, Xiao J, et al. A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study). Clin Cancer Res. 2022;28(19):4232-4239. doi:10.1158/1078-0432.CCR-22-0655CRITIQUES, RULES, AND NOTESBe aware of the following rules before posting comments:- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES:If your comment is rude, you will be banned.If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes. #cancer #vitaminc #cancertreatment

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomyJOIN THE COMMUNITYJoin my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2EMAIL LIST1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6HIRE ME FOR CONSULTING: Consulting: https://bit.ly/3dmUl2H Created with BiorenderNutrition Protocol with Vitamin C: https://youtu.be/phg_9Vv22fk?si=n_zBOymDvD8KtCpg0:00 - Introduction0:50 - Using Vitamin C on Cancer3:00 - Why was Vitamin C dismissed in the Past?5:05 - New Evidence...8:34 - Main PointsReferences[Study 547] Sun X, Cai X, Li S, et al. High-dose ascorbic acid selectively induces pyroptosis in LKB1-deficient lung cancer and sensitizes immunotherapy. Cell Rep Med. 2025;6(8):101234.Funding/Conflicts: Public funding: This study was supported by governmental agencies, including the National Natural Science Foundation of China, the Natural Science Foundation of Guangdong Province, the Regional Joint Fund Project of the Basic and Applied Basic Research Foundation of Guangdong Province, and the Science and Technology Projects in Guangzhou; Non-profit funding: No non-profit organization funding was reported; Industry funding: No industry funding was reported, and the authors stated that they have no competing interests or conflicts of interest.[A] Creagan ET, Moertel CG, O'Fallon JR, et al. Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med. 1979;301(13):687-690. doi:10.1056/NEJM197909273011303[B] Moertel CG, Fleming TR, Creagan ET, Rubin J, O'Connell MJ, Ames MM. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med. 1985;312(3):137-141. doi:10.1056/NEJM198501173120301[C] Jameson GS, LeGrand SD, Gordon MS, et al. Phase IB trial of high dose ascorbic acid + nab-paclitaxel + cisplatin + gemcitabine in patients with untreated metastatic pancreatic cancer. Redox Biol. Published online October 25, 2025. doi:10.1016/j.redox.2025.103895[D] Wang F, He MM, Xiao J, et al. A Randomized, Open-Label, Multicenter, Phase 3 Study of High-Dose Vitamin C Plus FOLFOX ± Bevacizumab versus FOLFOX ± Bevacizumab in Unresectable Untreated Metastatic Colorectal Cancer (VITALITY Study). Clin Cancer Res. 2022;28(19):4232-4239. doi:10.1158/1078-0432.CCR-22-0655CRITIQUES, RULES, AND NOTESBe aware of the following rules before posting comments:- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce). Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached. RULES:If your comment is rude, you will be banned.If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!). Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes. #cancer #vitaminc #cancertreatment

Mindsip insights from this episode:

Combine vitamin C with treatments to halt tumor growth

Vitamin C is most effective against cancer when combined with other treatments like immunotherapy, with the combination almost completely halting tumor growth.

Revise vitamin C trials to include intravenous doses and standard therapies

Early trials on vitamin C and cancer were unsuccessful because they relied on oral doses instead of intravenous and were not paired with standard cancer therapies.

Target LKB1 deficient lung cancer with vitamin C

Vitamin C is particularly effective against LKB1 deficient lung cancer because it increases damaging reactive oxygen species within those specific cells.

Combine vitamin C with nutrition for cancer defense

A simple nutrition protocol, not a drug, can be paired with vitamin C to create a potent combination effect against cancer.

Leverage short-term intravenous vitamin C for lasting survival benefits

In a human trial, just 12 cycles (about 5.5 months) of intravenous vitamin C showed a lasting effect on progression-free survival.

Target vitamin C's anti-cancer effects based on genetic features

Vitamin C's anti-cancer effects are specific to certain genetic features, such as colorectal cancers that have a Ras mutation.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius