Lose Fat With Science-Based Tools | Huberman Lab Essentials

Andrew Huberman

Apr 3, 2025

Episode description

In this Huberman Lab Essentials episode, I explore how the nervous system impacts fat loss and how certain behaviors and supplements can accelerate fat burning.

I explain how non-exercise movements like fidgeting and shivering trigger adrenaline to boost fat metabolism. I also examine the impact of exercise intensity and fasted workouts on fat burning, and how supplements such as caffeine, GLP-1 and berberine can further support fat loss. These science-based tools go beyond traditional calorie counting to enhance metabolism and improve body composition.

Episode show notes: https://go.hubermanlab.com/7L1cxrW

Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch or listen to the full-length episode: https://youtu.be/GqPGXG5TlZw

*Timestamps*
00:00:00 Huberman Lab Essentials; Fat Loss
00:01:00 Calories In, Calories Out; Nervous System
00:02:57 Fat Burning, Nervous System & Adrenaline
00:06:21 Increase Adrenaline, Shivering, Tool: Fidgeting
00:10:10 Shivering & Fat Loss, White & Brown Fat
00:13:27 Tool: Deliberate Cold Exposure Protocol
00:15:28 High, Medium vs Low-Intensity Exercise, Exercise Fasted?
00:21:21 Tool: Exercise for Fat Loss; Adrenaline
00:23:15 Caffeine, Dose, Exercise & Fat Loss
00:25:50 GLP-1, Yerba Mate, Exercise; Semaglutide
00:28:49 Berberine, Metformin, Insulin
00:29:46 Diet, Adherence, Carbohydrates & Insulin
00:31:25 Recap & Key Takeaways

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Episode description

Mindsip insights from this episode:

Leverage nervous system to enhance fat loss

The nervous system plays a crucial role in fat loss by governing how body fat is utilized. Neurons directly connect to fat cells, influencing fat mobilization and oxidation.

#fat

#nervous-system

Incorporate subtle movements to boost fat burning

Subtle movements like fidgeting can significantly enhance fat burning. Regular low-level activity throughout the day, like pacing or standing, can help offset caloric intake.

#exercise

#fat

Balance calories in and out for effective weight management

The fundamental principle of weight management is the balance of calories consumed versus calories burned. Eating more calories than you burn leads to weight gain, while eating less can result in fat loss.

#calories

#weight-loss

Utilize shivering to boost metabolism and promote fat loss

Shivering, tied to cold exposure, strongly stimulates fat mobilization and oxidation. Engaging in controlled cold exposure can enhance metabolic rates and promote fat loss.

#cold-therapy

#metabolism

Choose high-intensity interval training for effective fat loss

Different types of exercise affect fat loss differently. High-intensity interval training may accelerate fat burning compared to moderate activities, especially if performed in a fasted state.

#exercise

#weight-loss

Maximize fat burning with caffeine before workouts

Caffeine can enhance fat oxidation and metabolism when taken before exercise. Consuming it 30 to 40 minutes prior to working out helps maximize fat burning.

#fat

Boost fat oxidation with yerba mate before exercise

Drinks like yerba mate increase GLP-1, which aids in fat oxidation. This mechanism enhances fat burning, especially when consumed before exercise.

#fat

#GLP1

Balance insulin levels to enhance fat burning

Maintaining low insulin levels can promote fat oxidation. Choosing low to moderate carbohydrate diets can help keep insulin in check, facilitating greater fat burning.