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Created with Biorender

Fructose and Fiber: https://www.youtube.com/watch?v=KjEvuDQnqWQ

0:00 - Introduction
0:21 - Sugar, Sugar: You are My Candy Girl
2:08 - There’s Billions of Bad Guys
2:58 - There’s only one Poison, though
6:10 - Uniting Evidence in the Colon

References*
*Full Funding/Conflicts are provided in the free article (found in email list and Physionic Community Article Library)

[Study 716] Tang Y, Kuang J, Xia X, et al. Targeting microbiota-generated acetaldehyde to prevent progression of metabolic dysfunction-associated steatotic liver disease. Cell Metab. 2026;38:1-15. doi:10.1016/j.cmet.2026.01.021

Funding/Conflict: Public Funding: From the study, this work was supported by the Noncommunicable Chronic Diseases–National Science and Technology Major Project (2023ZD0507600 and 2025ZD0551000) and the National Natural Science Foundation of China; Non-Profit Funding: From the study, I did not find non-profit funding reported; Industry Funding: From the study, I did not find industry funding reported; Conflicts of Interest: From the study, the authors declared no competing interests.

[Study 535] Jung S, Bae H, Song WS, et al. Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis. Nat Metab. 2025;7(9):1801-1818. doi:10.1038/s42255-025-01356-0.

[Study 606] Ni Y, Qian L, Leal Siliceo S, et al. Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002

[1] Park WY, Yiannakou I, Petersen JM, Hoffmann U, Ma J, Long MT. Sugar-Sweetened Beverage, Diet Soda, and Nonalcoholic Fatty Liver Disease Over 6 Years: The Framingham Heart Study. Clin Gastroenterol Hepatol. 2022;20(11):2524-2532.e2. doi:10.1016/j.cgh.2021.11.001

[2] Johnston RD, Stephenson MC, Crossland H, et al. No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men. Gastroenterology. 2013;145(5):1016-1025.e2.
doi:10.1053/j.gastro.2013.07.012

[3] Maersk M, Belza A, Stødkilde-Jørgensen H, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. 2012;95(2):283-289. doi:10.3945/ajcn.111.022533

[4] Schwarz JM, Noworolski SM, Wen MJ, et al. Effect of a High-Fructose Weight-Maintaining Diet on Lipogenesis and Liver Fat. J Clin Endocrinol Metab. 2015;100(6):2434-2442. doi:10.1210/jc.2014-3678

[5] Daubioul CA, Horsmans Y, Lambert P, Danse E, Delzenne NM. Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study. Eur J Clin Nutr. 2005;59(5):723-726. doi:10.1038/sj.ejcn.1602127
[Study 606] Ni Y, Qian L, Leal Siliceo S, et al. Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002

[Study 608] Li H, Zhang L, Li J, et al. Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. Nat Metab. 2024;6(3):578-597. doi:10.1038/s42255-024-00988-y

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