PEARL Trial: A Blow to Rapamycin’s Healthspan Narrative?

Physionic

Oct 14, 2024

Episode description

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Created with Biorender

Video of PEARL Trial Researchers: https://youtu.be/dEXBFlQOTf4?si=i6bArV6i6Cfzl5Uo
Dr. Kaeberlein's Video: https://youtu.be/JUAXqSSnXzo?si=zAl5-ZxLQVsebDPq

Reference
[Study 346] Safety and efficacy of rapamycin on healthspan metrics after one year: PEARL Trial Results
Girish Harinath, Virginia Lee, Andy Nyquist, Mauricio Moel, Jesper Hagemeier, Stefanie L. Morgan, Anar Isman, Sajad Zalzala
medRxiv 2024.08.21.24312372; doi: https://doi.org/10.1101/2024.08.21.24312372

Industry Funding: AgelessRX // Potential Conflicts of Interest: Researchers are employees of Industry

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#rapamycin #longevityscience

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H


Created with Biorender

Video of PEARL Trial Researchers: https://youtu.be/dEXBFlQOTf4?si=i6bArV6i6Cfzl5Uo
Dr. Kaeberlein's Video: https://youtu.be/JUAXqSSnXzo?si=zAl5-ZxLQVsebDPq

Reference
[Study 346] Safety and efficacy of rapamycin on healthspan metrics after one year: PEARL Trial Results
Girish Harinath, Virginia Lee, Andy Nyquist, Mauricio Moel, Jesper Hagemeier, Stefanie L. Morgan, Anar Isman, Sajad Zalzala
medRxiv 2024.08.21.24312372; doi: https://doi.org/10.1101/2024.08.21.24312372

Industry Funding: AgelessRX // Potential Conflicts of Interest: Researchers are employees of Industry

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#rapamycin #longevityscience

Mindsip insights from this episode:

Confirm safety of low-dose rapamycin in PEARL trial

The PEARL trial was primarily a safety study and concluded that there were no serious adverse effects linked to rapamycin at the tested doses over 48 weeks.

Demand funding for definitive rapamycin clinical trials

A leading expert on rapamycin expressed immense frustration that funders have not stepped up to finance the definitive clinical trials needed to properly evaluate the drug.

Acknowledge limitations of healthy participants in study results

The study's ability to show significant effects was limited because many of the enrolled participants were already quite healthy.

Achieve small gains in bone and muscle with rapamycin

Even with a much lower than intended dose, the 10mg rapamycin group showed small improvements in bone mineral content and muscle mass.

Address dosing flaws in rapamycin trial for accurate results

The recent PEARL trial on rapamycin accidentally used doses that were only about 30% of the intended amount due to a packaging and bioavailability issue.

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