Using a wearable brain interface called Kernel Flow, it was possible to visually demonstrate how ketamine dramatically alters brain activity patterns in real-time and for several days after.

Psychedelics create a "therapeutic window" of brain plasticity after use, and the length of this window correlates with the drug's duration, lasting from a few days for ketamine to months for Ibogaine.

A study on patients with depression showed that six ketamine infusions were associated with a significant reduction in epigenetic biological age, such as a two-year decrease in PhenoAge.

Fentanyl poisoning is the leading cause of death for people aged 18 to 45 in the U.S., making it a major longevity threat for younger adults.

Due to the prevalence of fentanyl in street drugs, it is recommended that everyone have a kit with fentanyl test strips and Narcan (naloxone) nasal spray to prevent accidental overdose.

Ketamine temporarily scrambles the brain's established communication networks, like picking up and rearranging all the airports on Earth, which opens the mind to new ideas and patterns.

Heavy cocaine use can increase the risk of death by four to eight times, with one study equating daily use to an average loss of 10.8 years of life.

A study in mice suggests that combining ketamine with a drug called BCI, which inhibits DUSP6, can prolong the antidepressant-like effects and therapeutic window for up to eight weeks.