The #1 Anti-Aging Tool You’re Ignoring (Hint: It’s Free and Happens at Night)
Mark Hyman
Apr 14, 2025
Mindsip insights from this episode:
Leverage melatonin to boost fat burning through brown adipose tissue
Melatonin increases your body's mobilization of brown adipose tissue, a type of metabolically active fat that actually burns other fat.
Embrace night owl tendencies for potential benefits
Contrary to the 'early bird' saying, this philosophy suggests that night owls are not lazy and that waking up later can be beneficial.
Prioritize inflammation management over amyloid in Alzheimer's prevention
Research on a specific gene mutation found people were cognitively normal despite having brains full of amyloid, suggesting inflammation is the real trigger for Alzheimer's.
Limit sleep to avoid hormonal aging effects
Limiting sleep to four or five hours for just one week can lower a young man's testosterone to the level of someone 10 years his senior.
Use topical magnesium to improve sleep without digestive issues
To bypass the digestive issues that oral magnesium can cause, you can use a topical magnesium spray or lotion as an alternative.
Leverage gut melatonin to enhance sleep quality
Research found that there is upwards of 400 times more melatonin in your gut than in your pineal gland, highlighting the gut's role in sleep.
Limit melatonin supplements to preserve receptor function
Taking too much supplemental melatonin may not stop your body's own production, but it can downregulate the receptor sites that allow it to work.
Recognize sugar as a stressor that triggers hormone release
Your body responds to eating sugar or starch by releasing the stress hormones adrenaline and cortisol, even if you feel pleasure while eating it.
Prioritize sleep to fuel your brain and curb cravings
Just one night of sleep deprivation can reduce glucose reaching your brain by 14%, which is why you crave sugar and carbs when tired.
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