The Biohacks Big Pharma Doesn’t Want You to Know: Plasmapheresis, Muse Cells & Peptides

Mark Hyman

May 5, 2025

Episode description

Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health.

In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks.

Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world’s largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity.

Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur.

Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%.

Full-length episodes can be found here:

This Breakthrough Blood Therapy Could Add Years To Your Life Stem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing

Episode description

In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks.

This episode is brought to you by BIOptimizers.

Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%.

Full-length episodes can be found here:

This Breakthrough Blood Therapy Could Add Years To Your Life Stem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing

Mindsip insights from this episode:

Utilize BPC-157 to enhance tissue repair for injuries

The peptide BPC-157, nicknamed the "Wolverine peptide," systemically promotes tissue repair and can heal injuries even when injected far from the site of trauma.

#peptides

#regeneration

Remove old plasma to achieve rejuvenation

The key to rejuvenation is not adding factors from young blood, but rather removing the accumulated inflammatory molecules and toxins from old plasma.

#aging

#toxins

Combat fat accumulation in immune cells to reduce inflammation

With aging, immune cells called macrophages can accumulate fat, which prevents them from cleaning up debris and causes them to release pro-inflammatory signals.

#immune-system

#inflammation

Leverage MUSE cells for versatile stem cell applications

A newly discovered subtype called MUSE cells can survive harsh environments in the body, avoid getting trapped in the lungs, and differentiate into all cell types.

#stem-cell

Address challenges of first-generation IV stem cells to improve clinical outcomes

When administered intravenously, most first-generation mesenchymal stem cells get trapped in the lungs and die, leading to inconsistent clinical results.

#stem-cell

Beware misleading US stem cell clinics using committed progenitor cells

Many US stem cell clinics use "committed progenitor cells" from fat or bone marrow that only reduce inflammation, not regenerate new tissue like true stem cells.

#regeneration

#stem-cell

Utilize plasmapheresis to alleviate long COVID symptoms

A study from Germany showed that plasmapheresis can significantly reduce auto-antibodies and improve symptoms in patients with long COVID.

#COVID-19

#recovery

Reset longevity with Epithalon for cell cycle restoration

The peptide Epithalon, taken for 10 days twice a year, can act as a longevity reset by turning on the cell cycle and restoring the pineal gland's natural melatonin production.