The Future of Medicine Is Energy: Dr. Martin Picard Explains
Mark Hyman
Nov 19, 2025
Mindsip insights from this episode:
Cultivate optimism and purpose to enhance mitochondrial function
Research shows that psychological states like optimism and purpose are linked to having more and better-functioning mitochondria in the brain's prefrontal cortex.
Leverage ketogenic diet to enhance mental health through efficient energy use
The ketogenic diet may be transformative for mental health because ketones provide an energy source that faces less resistance in the mitochondria than glucose.
Balance stress and rest for optimal health
Health is built by cycling between periods of high energy resistance (like exercise) and low energy resistance (like rest), which is when adaptation and healing occur.
Recognize metabolic compensation to understand exercise energy burn
Your body compensates for calories burned during exercise by becoming more efficient and saving energy elsewhere, a process known as metabolic compensation.
Reduce energy resistance to combat fatigue
The feeling of fatigue or the pressure to sleep arises directly from your mitochondria when energy faces too much resistance to flow easily.
Recognize yourself as energy flowing through your body
A fundamental shift in perspective is to stop seeing the body as a machine powered by energy and to understand that you literally are the energy flowing through your body.
Find balance in energy resistance for optimal health
The Energy Resistance Principle proposes that life requires a 'sweet spot' of resistance for energy to be transformed, where too little is ineffective and too much causes disease.
Utilize GDF15 as a universal disease marker for chronic illness
The protein GDF15 is emerging as a pan-disease biomarker because it signals high 'energy resistance,' a common root cause of most chronic illnesses.
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