The Keto Cholesterol Study Has Gone HORRIBLY Wrong

Brad Stanfield

Apr 14, 2025

Episode description

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Here are the links to the research papers referenced in the video:
https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686
https://academic.oup.com/eurheartj/article/38/32/2459/3745109
https://clinicaltrials.gov/study/NCT05733325
https://pmc.ncbi.nlm.nih.gov/articles/PMC11426984/
https://x.com/AdrianSotoMota/status/1910045858152042999
https://x.com/MichaelMindrum/status/1911433670142931059
https://x.com/MichaelAlbertMD/status/1911448502229479738
https://x.com/DrNadolsky/status/1911411541112431029
https://x.com/upRootNutrition/status/1911496081797525523

Thumbnail by James Kelly
Video edited by Troy Young

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Mindsip insights from this episode:

Understand LDL cholesterol's dose-dependent risk for heart disease

Data from over two million people shows a consistent, dose-dependent, log-linear link between LDL cholesterol exposure and heart disease risk.

#heart

#LDL

Monitor plaque growth in keto diet participants

The plaque progression in the Keto CTA study was significantly faster than in a non-diabetic cohort and alarmingly close to the progression seen in a diabetic cohort.

#keto

#plaque

Challenge online narratives to make informed health choices

The speaker, a clinician, sees patients with very high LDL cholesterol who refuse to address it because of what they see from online influencers.

#cholesterol

#risk

Identify lean mass hyper-responders in low-carb diets

Lean mass hyper-responders are defined by a triad of high LDL cholesterol, high HDL cholesterol, and low triglycerides in lean individuals on a low-carbohydrate diet.

#cholesterol

#low-carb

Expose hidden outcomes in keto study for transparency

The Keto CTA study initially failed to report its primary outcome in written form with statistical analysis, which is considered a massive red flag in research.

#keto

#research

Reassess plaque progression estimates to reflect true impact

Researchers estimated plaque would progress by 7 units, but the actual result was 18.8 units, a figure only released after significant social media pressure.