The roughly 25% lean mass loss seen with GLP-1 drugs is not unique and is what doctors expect from any significant weight loss, including traditional dieting or surgery.

The speaker personally takes a low dose of 1.25mg of Tirzepatide weekly, even while lean, and protects his muscles with resistance training and adequate protein.

A new drug called Apidogromab successfully and safely blocks muscle loss by targeting the unique, inactive precursor form of myostatin, avoiding the side effects of previous attempts.

Besides resistance training and protein, creatine is a supplement worth considering as it is the most studied ingredient for improving muscle and strength.

In a recent trial, the drug Apidogromab successfully preserved lean muscle mass during weight loss, but it did not make the participants measurably stronger in functional tests.

Muscle-protecting peptides sold on the gray market, like YK11, have no proper human evidence and a real track record of causing liver damage.

A more powerful myostatin inhibitor, Bimagrumab, caused muscle growth but also had serious side effects, including muscle spasms and a 17% increase in LDL cholesterol.

The myostatin gene's only job in the body is to act as a brake on muscle growth, which is why a baby born without it was extraordinarily strong.