Given our current understanding and tools, atherosclerosis, the world's leading cause of death, should not even be in the top 10.

The four major impediments to lifespan are atherosclerosis, cancer, neurodegenerative disease, and metabolic disease, which acts as a risk amplifier for the other three.

Metabolic diseases like type 2 diabetes and fatty liver disease are dangerous primarily because they amplify the risk of heart disease, cancer, and neurodegenerative disease by about twofold.

The superpower of people who live to 100 is not that they live longer with chronic diseases, but that they delay the onset of these diseases by about two decades.

Standard medical practice often waits until a person's 10-year risk of a heart attack is high before acting, which is like waiting until you see the edge of a cliff before hitting the brakes.

An ApoB blood test is the most powerful predictor of cardiovascular disease and is very inexpensive, with a non-HDL cholesterol test being a 'poor man's substitute'.

ApoB, a protein that carries cholesterol, is a necessary but not sufficient cause for atherosclerosis, meaning you cannot get the disease without it.

Since high ApoB is known to cause atherosclerosis, we should aim to lower it early in life, just as we advise people to never start smoking to prevent lung cancer.