This Cheap Anti-inflammatory Cuts Heart Disease by 12%
Brad Stanfield
Jul 2, 2025
Episode description
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Here are the links to the research papers referenced in the video:
https://www.ncbi.nlm.nih.gov/books/NBK507799/
https://pmc.ncbi.nlm.nih.gov/articles/PMC5812812/
https://www.jrheum.org/content/39/7/1458
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00414-0/fulltext
https://www.nejm.org/doi/10.1056/NEJMoa2405922
https://www.bmj.com/content/385/bmj-2023-079061
https://academic.oup.com/eurheartj/advance-article-abstract/doi/10.1093/eurheartj/ehaf210/8123896
https://www.uptodate.com/contents/prevention-of-cardiovascular-disease-events-in-those-with-established-disease-secondary-prevention
https://www.sciencedirect.com/science/article/pii/S0735109721051159
https://www.jacc.org/doi/10.1016/j.jacadv.2025.101686
https://pmc.ncbi.nlm.nih.gov/articles/PMC8967417/
https://pmc.ncbi.nlm.nih.gov/articles/PMC2868080/
https://www.sciencedirect.com/science/article/pii/S0002916522036425
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2019.01550/full
https://link.springer.com/article/10.1007/s11818-025-00495-6
Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.
Mindsip insights from this episode:
Reduce excess body fat to combat systemic inflammation
Excess body fat directly contributes to systemic inflammation because it stimulates the production of pro-inflammatory chemicals.
Monitor LDL levels to prevent plaque progression in lean hyper-responders
A study on 'lean mass hyper-responders' found that even these otherwise very healthy individuals experience extremely rapid plaque progression due to sky-high LDL levels.
Maintain LDL cholesterol below 50-60 mg/dL to prevent arterial plaque
Even when all other health markers are perfect, arterial plaque still develops if LDL cholesterol is above the 50-60 mg/dL threshold.
Utilize colchicine to lower heart attack and stroke risk
A cheap anti-inflammatory drug for gout called colchicine, used since ancient Egypt, can reduce the risk of heart attacks and strokes in high-risk patients.
Recognize inflammation as a fire fueling heart disease
Inflammation is a critical driver of heart disease, acting like a smoldering fire in blood vessel walls that weakens them and accelerates plaque formation.
Break vicious plaque feedback loop to reduce inflammation
A vicious feedback loop occurs where trapped LDL in artery walls drives more inflammation, which in turn causes more LDL to get stuck, accelerating plaque.
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