This Cheap Anti-inflammatory Cuts Heart Disease by 12%
Brad Stanfield
Jul 2, 2025
Mindsip insights from this episode:
Reduce excess body fat to combat systemic inflammation
Excess body fat directly contributes to systemic inflammation because it stimulates the production of pro-inflammatory chemicals.
Monitor LDL levels to prevent plaque progression in lean hyper-responders
A study on 'lean mass hyper-responders' found that even these otherwise very healthy individuals experience extremely rapid plaque progression due to sky-high LDL levels.
Maintain LDL cholesterol below 50-60 mg/dL to prevent arterial plaque
Even when all other health markers are perfect, arterial plaque still develops if LDL cholesterol is above the 50-60 mg/dL threshold.
Utilize colchicine to lower heart attack and stroke risk
A cheap anti-inflammatory drug for gout called colchicine, used since ancient Egypt, can reduce the risk of heart attacks and strokes in high-risk patients.
Recognize inflammation as a fire fueling heart disease
Inflammation is a critical driver of heart disease, acting like a smoldering fire in blood vessel walls that weakens them and accelerates plaque formation.
Break vicious plaque feedback loop to reduce inflammation
A vicious feedback loop occurs where trapped LDL in artery walls drives more inflammation, which in turn causes more LDL to get stuck, accelerating plaque.
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