What Every Woman MUST KNOW to PREVENT Alzheimer’s | Neuroscientist Lisa Mosconi X Rich Roll Podcast

Rich Roll

Mar 11, 2024

Episode description

Rich sits down with neuroscientist Dr. Lisa Mosconi to discuss menopause and brain health, Alzheimer’s and dementia, neuro-nutrition, hormone replacement therapy, and much more. To read more about Dr. Mosconi and peruse the full show notes, go here👉🏾https://bit.ly/richroll819
✌🏼🌱 - Rich

This Episode Brought To You By...

SQUARESPACE
Get 10% OFF with code RichRoll 👉 https://bit.ly/squarespace2024

SEED
Use code RICHROLL25 for 25% OFF 👉 https://bit.ly/seed2024

LISTEN / SUBSCRIBE TO THE PODCAST
Apple Podcasts: http://bit.ly/rrpitunes
Spotify: http://bit.ly/rrpspotify
Google: http://bit.ly/rrpgooglepods

Meal Planner: http://meals.richroll.com
Voicing Change Book: http://richroll.com/vc
Clips Channel: https://www.youtube.com/c/RichRollPodcastClips
Newsletter: http://bit.ly/rollcallemail

CONNECT WITH RICH
✩ Website - http://richroll.com​
✩ Rich Roll Podcast - https://richroll.com/all-episodes/
✩ Instagram - https://www.instagram.com/richroll/
✩ Twitter - https://twitter.com/richroll
✩ Facebook - https://www.facebook.com/richrollfans
✩ Strava - https://www.strava.com/athletes/14443?oq=rich
✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/finding-ultra/
✩ Meals - http://meals.richroll.com​
✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/the-plantpower-way-signed/
✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/the-plantpower-way-italia-signed/
✩ Support - https://www.patreon.com/richroll

FILMED AND EDITED BY BLAKE CURTIS, DAN DRAKE AND MORGAN MCRAE
https://www.blakecurtis.net/
https://www.dandrake333.com/

TIMESTAMPS
00:00:00 Intro
00:01:15 Dr. Mosconi's Background
00:03:34 Interest in Neuroscience
00:04:37 Move to the United States
00:06:14 Gender Disparities in Alzheimer's
00:08:27 Historical Context of Women's Health in Science
00:15:16 Bikini Medicine
00:19:16 Sex Differences in Brain Aging
00:22:46 Understanding Menopause
00:23:57 Impact of Menopause on the Brain
00:25:36 Research Gap in Menopause and Brain Imaging
00:26:34 Brain Scans and Menopausal Status
00:29:17 Genetic Predisposition to Alzheimer's
00:31:57 Sponsor Break
00:33:05 Back To Show
00:34:31 Apolipoprotein E (APOE) Gene
00:38:28 Menopause and Cognitive Changes
00:49:16 Evolutionary Perspective on Menopause
00:49:35 Brain Scans and Menopausal Changes
00:53:43 Menopause and Brain Changes
00:55:47 Differential Menopausal Experiences
00:56:13 Menopause Types and Health Risks
00:58:02 Hysterectomy and Alzheimer's Risk
00:58:47 Induced Menopause and Cancer Treatments
00:59:52 Understanding Alzheimer's and Dementia
01:02:06 Sponsor Break
01:03:13 Cardiovascular Health and Dementia
01:05:55 Lifestyle and Brain Health
01:11:53 Neuro-Nutrition and Brain Health
01:17:30 Antioxidant-Rich Foods
01:19:35 Supplementation and Nutritional Deficiencies
01:21:57 Antioxidants and Brain Health
01:23:02 Fiber and Hormonal Health
01:24:05 Microbiome and Hormonal Health
01:27:47 Exercise Intensity and Brain Health
01:32:11 Consistency and Long-Term Impact of Lifestyle Changes
01:36:05 Hormone Replacement Therapy and Alzheimer's Risk
01:45:07 Hormone Replacement Therapy
01:46:30 Estrogen Only Formulations
01:49:28 Timing and Type of Hormone Therapy
01:50:26 Brain Scans and Designer Estrogen
01:54:20 Pharmacological Interventions
01:55:41 Diet and Menopause
01:57:10 Sleep and Brain Health
02:06:18 Baseline Testing
02:11:15 Brain Scans and Alzheimer's Prevention Program
02:15:12 Media's Relationship to Health Information
02:16:16 Social Media and Information Accuracy
02:22:08 Scientists and Doctors' Communication Challenges
02:23:22 Science Communication and Public Understanding
02:23:59 Closing Remarks/Credits

* * * * *

NEW TO RICH?
Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
http://bit.ly/otillonyt
http://bit.ly/vegansglam

I LOVE MAIL! SEND IT HERE:
2630 Conejo Spectrum St.
Thousand Oaks, CA 91320

#richroll #richrollpodcast

Episode description

Rich sits down with neuroscientist Dr. Lisa Mosconi to discuss menopause and brain health, Alzheimer’s and dementia, neuro-nutrition, hormone replacement therapy, and much more. To read more about Dr. Mosconi and peruse the full show notes, go here👉🏾https://bit.ly/richroll819
✌🏼🌱 - Rich

This Episode Brought To You By...

SQUARESPACE
Get 10% OFF with code RichRoll 👉 https://bit.ly/squarespace2024

SEED
Use code RICHROLL25 for 25% OFF 👉 https://bit.ly/seed2024

LISTEN / SUBSCRIBE TO THE PODCAST
Apple Podcasts: http://bit.ly/rrpitunes
Spotify: http://bit.ly/rrpspotify
Google: http://bit.ly/rrpgooglepods

Meal Planner: http://meals.richroll.com
Voicing Change Book: http://richroll.com/vc
Clips Channel: https://www.youtube.com/c/RichRollPodcastClips
Newsletter: http://bit.ly/rollcallemail

CONNECT WITH RICH
✩ Website - http://richroll.com​
✩ Rich Roll Podcast - https://richroll.com/all-episodes/
✩ Instagram - https://www.instagram.com/richroll/
✩ Twitter - https://twitter.com/richroll
✩ Facebook - https://www.facebook.com/richrollfans
✩ Strava - https://www.strava.com/athletes/14443?oq=rich
✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/finding-ultra/
✩ Meals - http://meals.richroll.com​
✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/the-plantpower-way-signed/
✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/the-plantpower-way-italia-signed/
✩ Support - https://www.patreon.com/richroll

FILMED AND EDITED BY BLAKE CURTIS, DAN DRAKE AND MORGAN MCRAE
https://www.blakecurtis.net/
https://www.dandrake333.com/

TIMESTAMPS
00:00:00 Intro
00:01:15 Dr. Mosconi's Background
00:03:34 Interest in Neuroscience
00:04:37 Move to the United States
00:06:14 Gender Disparities in Alzheimer's
00:08:27 Historical Context of Women's Health in Science
00:15:16 Bikini Medicine
00:19:16 Sex Differences in Brain Aging
00:22:46 Understanding Menopause
00:23:57 Impact of Menopause on the Brain
00:25:36 Research Gap in Menopause and Brain Imaging
00:26:34 Brain Scans and Menopausal Status
00:29:17 Genetic Predisposition to Alzheimer's
00:31:57 Sponsor Break
00:33:05 Back To Show
00:34:31 Apolipoprotein E (APOE) Gene
00:38:28 Menopause and Cognitive Changes
00:49:16 Evolutionary Perspective on Menopause
00:49:35 Brain Scans and Menopausal Changes
00:53:43 Menopause and Brain Changes
00:55:47 Differential Menopausal Experiences
00:56:13 Menopause Types and Health Risks
00:58:02 Hysterectomy and Alzheimer's Risk
00:58:47 Induced Menopause and Cancer Treatments
00:59:52 Understanding Alzheimer's and Dementia
01:02:06 Sponsor Break
01:03:13 Cardiovascular Health and Dementia
01:05:55 Lifestyle and Brain Health
01:11:53 Neuro-Nutrition and Brain Health
01:17:30 Antioxidant-Rich Foods
01:19:35 Supplementation and Nutritional Deficiencies
01:21:57 Antioxidants and Brain Health
01:23:02 Fiber and Hormonal Health
01:24:05 Microbiome and Hormonal Health
01:27:47 Exercise Intensity and Brain Health
01:32:11 Consistency and Long-Term Impact of Lifestyle Changes
01:36:05 Hormone Replacement Therapy and Alzheimer's Risk
01:45:07 Hormone Replacement Therapy
01:46:30 Estrogen Only Formulations
01:49:28 Timing and Type of Hormone Therapy
01:50:26 Brain Scans and Designer Estrogen
01:54:20 Pharmacological Interventions
01:55:41 Diet and Menopause
01:57:10 Sleep and Brain Health
02:06:18 Baseline Testing
02:11:15 Brain Scans and Alzheimer's Prevention Program
02:15:12 Media's Relationship to Health Information
02:16:16 Social Media and Information Accuracy
02:22:08 Scientists and Doctors' Communication Challenges
02:23:22 Science Communication and Public Understanding
02:23:59 Closing Remarks/Credits

* * * * *

NEW TO RICH?
Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
http://bit.ly/otillonyt
http://bit.ly/vegansglam

I LOVE MAIL! SEND IT HERE:
2630 Conejo Spectrum St.
Thousand Oaks, CA 91320

#richroll #richrollpodcast

Mindsip insights from this episode:

Nourish your estrobolome with plant-based foods

A community of gut bacteria called the estrobolome helps regulate estrogen levels, and it thrives on plant-based foods like onions, asparagus, and ginger.

Initiate estrogen-only therapy within 10 years of menopause to lower dementia risk

A meta-analysis of nearly 6 million women shows taking estrogen-only hormone therapy within 10 years of menopause is linked to a 32% reduced dementia risk.

Utilize Phytoserm to enhance brain function without reproductive impact

A new drug called Phytoserm is a selective estrogen receptor modulator engineered to support brain function without affecting reproductive tissue.

Incorporate antioxidants into your diet to protect brain health

The brain's high metabolic activity creates oxidative stress, and the only way to combat the resulting free radicals is to import antioxidants from your diet.

Seek professional counseling for genetic testing insights

Finding out you have a genetic risk factor like the APOE4 gene from a direct-to-consumer test can be psychologically harmful, so professional genetic counseling is imperative.

Prioritize moderate exercise for better menopause health outcomes

For menopausal women, moderate-intensity exercise may be more beneficial for health outcomes than high-intensity exercise, which can negatively impact sex hormones.

Leverage grandmother hypothesis to understand evolutionary advantages of menopause

The grandmother hypothesis suggests menopause is an evolutionary advantage, allowing older women to help their children have more children, thus passing on their longevity genes.

Recognize menopause as a neurological transition

Menopause is a neurologically active transition state during which your brain is impacted just as much as your ovaries are, sometimes more.

Understand brain's cholesterol production and its protective role

The brain makes its own cholesterol and shields it from the rest of the body, so dietary cholesterol will not get inside a healthy brain.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius