What Stress, Burnout, And Hustle Culture Do To Your Body | Bryan Johnson Podcast

Bryan Johnson

Jul 31, 2025

Episode description

Studies
Burnout + Heart Attack Risk: https://pmc.ncbi.nlm.nih.gov/articles/PMC10909938/
Hours Worked + Heart Disease: https://www.sciencedirect.com/science/article/pii/S0160412021002208
Sleep Deprivation in CEOs: https://pubmed.ncbi.nlm.nih.gov/27159583/
Sleep Deprivation in Judges: https://www.pnas.org/doi/full/10.1073/pnas.1018033108

🥦 Start your Blueprint protocol: https://blueprint.bryanjohnson.com/?&utm_source=youtube&utm_medium=video&utm_content=tv875KnuuMg
📩 Subscribe for my latest protocols: https://dontdie.bryanjohnson.com/?&utm_source=youtube&utm_medium=video&utm_content=tv875KnuuMg

Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson

Let’s be friends:
Twitter: https://x.com/bryan_johnson
Instagram: https://www.instagram.com/bryanjohnson_
TikTok: https://www.tiktok.com/@_bryan_johnson_

Chapters
0:00 - Intro
03:11 - Martyring Yourself for Success
15:50 - Study: ‘Overwork Will Kill You’
20:04 - Sleep + Decision Making (Studies)
25:54 - Physical Fitness + Diet (Studies)
28:24 - Treating Health Like Religion
33:30 - Tips for Balancing Work and Health
43:58 - Resting Heart Rate Before Bed
47:06 - Protecting Your Agency

Episode description

Studies
Burnout + Heart Attack Risk: https://pmc.ncbi.nlm.nih.gov/articles/PMC10909938/
Hours Worked + Heart Disease: https://www.sciencedirect.com/science/article/pii/S0160412021002208
Sleep Deprivation in CEOs: https://pubmed.ncbi.nlm.nih.gov/27159583/
Sleep Deprivation in Judges: https://www.pnas.org/doi/full/10.1073/pnas.1018033108

🥦 Start your Blueprint protocol: https://blueprint.bryanjohnson.com/?&utm_source=youtube&utm_medium=video&utm_content=tv875KnuuMg
📩 Subscribe for my latest protocols: https://dontdie.bryanjohnson.com/?&utm_source=youtube&utm_medium=video&utm_content=tv875KnuuMg

Hosts:
Bryan Johnson: Blueprint Founder
Kate Tolo: Blueprint Co-Founder
Dr. Mike Mallin: Lead Physician for Bryan Johnson

Let’s be friends:
Twitter: https://x.com/bryan_johnson
Instagram: https://www.instagram.com/bryanjohnson_
TikTok: https://www.tiktok.com/@_bryan_johnson_

Chapters
0:00 - Intro
03:11 - Martyring Yourself for Success
15:50 - Study: ‘Overwork Will Kill You’
20:04 - Sleep + Decision Making (Studies)
25:54 - Physical Fitness + Diet (Studies)
28:24 - Treating Health Like Religion
33:30 - Tips for Balancing Work and Health
43:58 - Resting Heart Rate Before Bed
47:06 - Protecting Your Agency

Mindsip insights from this episode:

Establish non-negotiable health routines to safeguard well-being

Establishing non-negotiable health routines is crucial because high-achievers are very good at convincing themselves to make exceptions.

Prioritize health and sleep for greater success and wealth

The founder of Braintree and Venmo believes he would have been more successful and made more money if he had prioritized his health and sleep.

Schedule difficult conversations before 5 PM to protect relationships

To maintain relationship health, avoid having difficult or emotional conversations after 5 PM, as decision fatigue and low energy dramatically increase the chance of a negative outcome.

Optimize decision-making by avoiding fatigue before lunch

A study of Israeli judges found they granted parole to 65% of applicants in the morning but 0% right before lunch, demonstrating how fatigue dramatically impacts critical decision-making.

Address burnout to reduce heart attack risk by 78%

A 2022 meta-analysis concluded that burnout increases the risk of a heart attack by a staggering 78%.

Utilize red light therapy to enhance sleep duration

Using red and near-infrared light therapy at an exposure of 32 joules/cm² before bed resulted in an extra hour of sleep on the first night of an experiment.

Prioritize sleep by treating it as a job, nurturing it with compassion, and setting boundaries

To prioritize sleep, you can treat it like a job, approach it with self-compassion as if caring for a child, or seek social permission from peers to set healthy boundaries.

Limit ultra-processed food to reduce dementia risk

Each daily serving of ultra-processed food increases your risk of dementia by approximately 13%.

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