Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah
Dave Asprey
May 9, 2025
Mindsip insights from this episode:
Lower SHBG to enhance free testosterone with Kyzatrex
The oral testosterone Kyzatrex has been shown to lower Sex Hormone Binding Globulin (SHBG) by up to 50%, which preferentially increases the amount of usable free testosterone.
Leverage testosterone to enhance mitochondrial health
Testosterone operates down to a cellular level, directly affecting mitochondrial health through processes like mitophagy and calcium regulation.
Address low testosterone levels for optimal health
The speakers claim that essentially everyone alive is low in testosterone unless they are on an aggressive program to address it.
Prioritize testosterone level as key health marker
Your testosterone level can be considered the single best marker of your overall health, even more indicative than cholesterol or blood pressure.
Recognize women's higher testosterone levels before menopause
Contrary to popular belief, women naturally have more testosterone than estrogen, with levels being four to five times higher before menopause.
Utilize Kyzatrex for safer oral testosterone without liver toxicity
A next-generation oral testosterone product, Kyzatrex, is absorbed lymphatically through the small intestine, which avoids the liver toxicity associated with older oral forms.
Mimic testosterone's natural rhythm with twice-daily dosing
Taking oral testosterone twice daily (morning and lunch) mimics the body's natural circadian rhythm, preventing the suppression of your body's own signaling hormones like LH and FSH.
Utilize chrysin and calcium D-glucarate to manage estrogen conversion
The herb Chrysin and the supplement Calcium D-glucarate can help manage the conversion of testosterone to estrogen and aid the liver in clearing it.
Recognize testosterone's cardioprotective benefits after FDA warning reversal
The FDA has recently removed its black box warning suggesting testosterone causes cardiovascular risk, acknowledging data that it is actually cardioprotective.
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