Why Oral Testosterone Is the Ultimate Upgrade for Energy, Mood and Longevity (Men AND Women) | Shalin Shah

Dave Asprey

May 9, 2025

Episode description

Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.

In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before.

You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself.

Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects.

What You Will Learn in This Episode:

• Why testosterone matters for men and women at every age

• The real causes of the global testosterone crash

• Why diet, sleep, and exercise cannot fully fix low testosterone

• How testosterone drives dopamine, motivation, and longevity

• The breakthrough that makes oral testosterone safe and effective

• How Kyzatrex® lowers SHBG and boosts free testosterone naturally

• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan

• How to safely use testosterone therapy without suppressing fertility or causing side effects

** Visit livethrive.co/asprey to get a discount on your first month's supply! **

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey

• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree:

Mindsip insights from this episode:

Lower SHBG to enhance free testosterone with Kyzatrex

The oral testosterone Kyzatrex has been shown to lower Sex Hormone Binding Globulin (SHBG) by up to 50%, which preferentially increases the amount of usable free testosterone.

#testosterone

Leverage testosterone to enhance mitochondrial health

Testosterone operates down to a cellular level, directly affecting mitochondrial health through processes like mitophagy and calcium regulation.

#mitochondria

#testosterone

Address low testosterone levels for optimal health

The speakers claim that essentially everyone alive is low in testosterone unless they are on an aggressive program to address it.

#testosterone

Prioritize testosterone level as key health marker

Your testosterone level can be considered the single best marker of your overall health, even more indicative than cholesterol or blood pressure.

#health

#testosterone

Recognize women's higher testosterone levels before menopause

Contrary to popular belief, women naturally have more testosterone than estrogen, with levels being four to five times higher before menopause.

#menopause

#testosterone

Utilize Kyzatrex for safer oral testosterone without liver toxicity

A next-generation oral testosterone product, Kyzatrex, is absorbed lymphatically through the small intestine, which avoids the liver toxicity associated with older oral forms.

#Medication

#testosterone

Mimic testosterone's natural rhythm with twice-daily dosing

Taking oral testosterone twice daily (morning and lunch) mimics the body's natural circadian rhythm, preventing the suppression of your body's own signaling hormones like LH and FSH.

#circadian

#testosterone

Utilize chrysin and calcium D-glucarate to manage estrogen conversion

The herb Chrysin and the supplement Calcium D-glucarate can help manage the conversion of testosterone to estrogen and aid the liver in clearing it.

#estrogen

#supplement

Recognize testosterone's cardioprotective benefits after FDA warning reversal

The FDA has recently removed its black box warning suggesting testosterone causes cardiovascular risk, acknowledging data that it is actually cardioprotective.