Ergothioneine: New Supplement discovered to Improve Mitochondrial Function [Study 295]

Physionic

27 may 2024

Episode description

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References [Copy & Paste DOI into Search Engine]
[1] [Study 295] doi:10.1101/2024.04.10.588849

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#mitochondrialhealth

Episode description

Mindsip insights from this episode:

Boost ergothioneine levels in muscle mitochondria through exercise

A new, unpublished study shows that exercise increases concentrations of the amino acid ergothioneine within muscle mitochondria.

#exercise

#mitochondria

Boost ergothioneine function through exercise

Exercise not only increases ergothioneine levels but also increases the expression of the MPST enzyme that ergothioneine requires to function.

#enzyme

#exercise

Boost ergothioneine levels through endurance and resistance training

Data from previous human studies confirms that both endurance and resistance training increase the levels of ergothioneine found in the blood.

#exercise

#metabolism

Boost physical performance by supplementing ergothioneine

In a mouse study, supplementing the diet with ergothioneine improved physical performance by almost 30% without any additional exercise.

#supplement

Ensure MPST enzyme for ergothioneine's mitochondrial benefits

The mitochondrial benefits of ergothioneine are dependent on an enzyme called MPST, as inhibiting this enzyme negates ergothioneine's positive effects.

#enzyme

#mitochondria

Boost mitochondrial function with ergothioneine supplementation

When added directly to muscle cells in a lab, ergothioneine was shown to increase oxygen consumption, which is a direct proxy for improved mitochondrial function.