In this episode, my guest is Dr. Matthew Hill, a professor of cell biology and anatomy at the Hotchkiss Brain Institute at the University of Calgary and an expert on the biology of cannabis. We discuss how cannabis affects the brain to produce its psychoactive effects (feeling “high”), including altered time perception, focus, memory, appetite, and stress.

We discuss how THC vs. cannabidiol (CBD) affects the brain, the effects of different routes of cannabis administration (e.g., smoking, vaping, edibles), high-potency THC, and whether cannabis is addictive. We discuss if there is a link between cannabis use and the development of psychosis, anxiety, bipolar depression, or schizophrenia.

We discuss whether CBD has clinical benefits in regulating stress, promoting sleep, and treating certain diseases. We also discuss if there are real and consistent differences in the biological effects of different cannabis strains, if cannabis impacts hormones, and the uses of cannabis for the management of pain, stress, Post-traumatic stress disorder (PTSD), anxiety, and nausea.

Listeners of this episode will get an up-to-date understanding of what is currently known about how cannabis affects the brain and body, including both its potential benefits and risks.

Access the full show notes for this episode at https://www.hubermanlab.com/episode/dr-matthew-hill-how-cannabis-impacts-health-the-potential-risks

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Dr. Matthew Hill
Hotchkiss Brain Institute: https://hbi.ucalgary.ca/mist/team/research-chair
University of Calgary academic profile: https://profiles.ucalgary.ca/matthew-hill
Publications: https://scholar.google.ca/citations?user=Q494JnAAAAAJ&hl=en&oi=ao
Lab website: http://www.hill-lab.ca/
X: https://x.com/canna_brain

Timestamps
00:00:00 Dr. Matthew Hill
00:00:00 Sponsors: Eight Sleep, LMNT & BetterHelp
00:07:16 Cannabis, THC, Cannabidiol (CBD), Terpenes
00:12:08 Psychoactive Effects, Cannabis “High”; Time Perception
00:16:55 Cannabis & Brain, CB1 Receptor, Endocannabinoids
00:26:19 Endocannabinoids Types: Anandamide, 2-AG
00:33:46 “Munchies”, Cannabis & Appetite
00:42:17 Sponsor: AG1
00:44:06 THC & Anandamide, Pharmacology
00:52:37 THC & CB1 Receptors, Intoxication & Appetite
00:58:57 Cannabis & Focus, Memory
01:04:09 Routes of Administration, Concentration, Cannabis Research
01:15:12 Self-Regulation, Inhalation & THC, Tolerance; THC Concentrates
01:22:25 Sponsor: InsideTracker
01:23:36 Addiction & Cannabis, Cannabis Use Disorder
01:31:30 Cannabis Legalization & Use, Edibles & ER Visits
01:36:48 Oral Consumption, Edibles, Dosing & Time Course
01:41:12 Drug Testing & Cannabis, Exercise
01:46:04 Cannabis & Hormones, Gynecomastia, Sperm Quality
01:54:37 Cannabis & Pregnancy; Selling Recreational Cannabis
02:04:07 Vaping
02:07:05 Psychosis, Anxiety & Cannabis
02:17:17 Cannabis, Psychosis, Schizophrenia & Genetics
02:30:45 Cannabis Use & Schizophrenia, Manic Bipolar, THC Potency, Nicotine
02:40:37 Schizophrenia, Cannabis Legalization
02:45:06 Cannabis Strains, Indica, Sativa, Subjective Effects & Expectancy Bias
02:57:00 CBD, Pediatric Epilepsy, Adenosine
03:07:22 Entourage Effect; Placebo Effect, CBD & Doses
03:19:12 Cannabis Health Risks, Cardiovascular Risk, Schizophrenia
03:27:08 Cyclic Vomiting Syndrome & Hot Shower
03:31:30 Cannabis Benefits: Pain, Stress, Anxiety, Post-Traumatic Stress Disorder (PTSD)
03:40:18 Cannabis & Anxiety, Anandamide & Stress Response
03:45:55 Scientific Discussion, Clarification & Advancement
03:49:47 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter

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Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com

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