This FASCINATING Molecule Originally Boosted Muscle & Endurance But Is *Now* Being Shown To Reverse Immune Aging?! Urolithin A With Dr. Anurag Singh
Ben Greenfield
4 sept 2025
Mindsip insights from this episode:
Pursue solutions to enhance muscle, immune, and cognitive health by 10 years
The next frontier in longevity may be finding a single solution that simultaneously improves muscle, immune, and cognitive health by 10 years, which is the goal of a Peter Diamandis X-Prize.
Boost mitochondria through exercise, creatine, and Urolithin A
You can boost mitochondria through biogenesis (via exercise), efficiency (via creatine or CoQ10), and mitophagy or cellular cleanup (via Urolithin A).
Juice 60 pomegranates for effective Urolithin A dose
To get a clinically effective 1000mg dose of Urolithin A from food, you would need to juice approximately 60 pomegranates.
Recharge immune cells with Urolithin A to combat cancer
Research shows Urolithin A recharges the mitochondria of critical immune cells, including Natural Killer (NK) cells and cytotoxic T-cells, which are crucial for fighting cancer.
Utilize Urolithin A and Ozempic to enhance CAR-T cell therapy
A recent study screening 8,000 compounds found that only Urolithin A and a GLP-1 drug (like Ozempic) could recharge specialized CAR-T immune cells used in cancer therapy.
Take 1 gram of Urolithin A for immune support
Clinical trials consistently show that a 1-gram dose of Urolithin A is needed to see significant effects on the immune system, such as lowering the whole-body inflammation marker C-reactive protein (CRP).
Prioritize immune health to combat aging triggers
A unique perspective is that immune aging is the central piece and primary trigger for many of the other hallmarks of aging, not just one of many equal factors.
Balance your immune system with urolithin A as a modulator
Urolithin A acts as an 'immune modulator,' meaning it can strengthen a weak, fatigued immune system while also reining in an overactive one to maintain balance.
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