Cleo Abram: Metformin, the Anti-Aging Drug… or is it?

Physionic

Jun 26, 2024

Episode description

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References [Copy and Paste DOI into Search]
[1] doi: 10.1111/dom.12354
[2] doi: 10.1093/ije/dyac200

Cleo's Video: https://youtu.be/sFbghkE0WYo?si=AiOoZ6o4iujV9wel

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#metformin #antiaging #hugeiftrue

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H


Created with Biorender

References [Copy and Paste DOI into Search]
[1] doi: 10.1111/dom.12354
[2] doi: 10.1093/ije/dyac200

Cleo's Video: https://youtu.be/sFbghkE0WYo?si=AiOoZ6o4iujV9wel

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#metformin #antiaging #hugeiftrue

Mindsip insights from this episode:

Leverage metformin for improved longevity in diabetics

In a large UK retrospective study, people with diabetes taking metformin surprisingly had lower mortality rates than a control group of healthy people without diabetes.

Advocate for FDA approval of aging as a treatable condition

The upcoming TAME clinical trial is designed to convince the FDA to approve drugs specifically for "aging" as a treatable condition, using metformin as the test case.

Reassess metformin's effectiveness against healthy controls

A follow-up study correcting the original's flaws showed that metformin does not lead to superior survival compared to healthy people not taking the drug.

Critique flawed metformin study on longevity claims

The popular study suggesting metformin users outlived healthy individuals was flawed because it excluded patients from the analysis as their diabetes worsened, artificially boosting the results.

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