
Cleo Abram: Metformin, the Anti-Aging Drug… or is it?
Physionic
Jun 26, 2024
Mindsip insights from this episode:
Leverage metformin for improved longevity in diabetics
In a large UK retrospective study, people with diabetes taking metformin surprisingly had lower mortality rates than a control group of healthy people without diabetes.
Advocate for FDA approval of aging as a treatable condition
The upcoming TAME clinical trial is designed to convince the FDA to approve drugs specifically for "aging" as a treatable condition, using metformin as the test case.
Reassess metformin's effectiveness against healthy controls
A follow-up study correcting the original's flaws showed that metformin does not lead to superior survival compared to healthy people not taking the drug.
Critique flawed metformin study on longevity claims
The popular study suggesting metformin users outlived healthy individuals was flawed because it excluded patients from the analysis as their diabetes worsened, artificially boosting the results.
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