Dementia Rates PLUNGED in Study of 1 Million People

Brad Stanfield

Nov 6, 2025

Episode description

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Timestamps:
00:00 Concerns About Cholesterol-Lowering and Brain Health
01:22 Evidence of Statins Affecting Brain Health
02:41 Statins and Dementia Risk
04:38 Contradiction Between Observational Studies and Randomised Control Trials
06:13 New Study on Cholesterol-Lowering Medications and Dementia Risk
09:19 Practical Takeaways for Lowering Dementia Risks
13:26 Supplements for Brain Health

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Here are the links to the research papers referenced in the video:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6844833/
https://pubmed.ncbi.nlm.nih.gov/22269162/
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-018-0110-3
https://pubmed.ncbi.nlm.nih.gov/12885101/
https://pubmed.ncbi.nlm.nih.gov/19653027/
https://evidence.nejm.org/doi/full/10.1056/EVIDoa2400112
https://pmc.ncbi.nlm.nih.gov/articles/PMC11736423/
https://www.ncbi.nlm.nih.gov/books/NBK430817/
https://www.mdpi.com/2813-2564/4/1/2
https://www.nature.com/articles/s41598-022-24153-1
https://pmc.ncbi.nlm.nih.gov/articles/PMC11830700/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12341882/
https://www.sciencedirect.com/science/article/pii/S2405650225000449
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70638
https://pmc.ncbi.nlm.nih.gov/articles/PMC6380691
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2824%2901296-0/abstract
https://pmc.ncbi.nlm.nih.gov/articles/PMC11103094/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8912287/
https://academic.oup.com/nutritionreviews/advance-article/doi/10.1093/nutrit/nuac064/6671817
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7569385/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610948/

Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken

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Mindsip insights from this episode:

Enhance memory performance in older adults with creatine supplements

Creatine supplements, often used for muscle building, have been shown in a meta-analysis to improve memory performance, with a particularly strong effect in older adults.

#creatine

#memory

Take daily multivitamins to slow brain aging by two years

Taking a daily multivitamin and mineral supplement was found in one trial to be equivalent to reducing the aging of the brain by two years.

#aging

#supplement

Simulate lifelong statin use to reduce dementia risk by 76%

A Mendelian randomization trial, which mimics lifelong statin use through genetics, found a 76% relative risk reduction for dementia.

#dementia

#statin

Mitigate dementia risk by addressing hearing loss with aids

For every 10 decibels of hearing loss your dementia risk goes up by 16%, but using hearing aids can significantly lower this risk.

#dementia

#hearing

Use TMG to lower homocysteine and prevent Alzheimer's

The supplement TMG may help prevent Alzheimer's disease by lowering high levels of homocysteine, an amino acid strongly linked to the disease.

#Alzheimer's

#TMG

Treat midlife depression to lower dementia risk by 30%

Depression in midlife more than doubles the risk of developing dementia later on, but treatment can reduce this risk by about 30%.

#dementia

#depression

Incorporate microvitamin plus for optimal supplementation

The speaker personally takes a powder called microvitamin plus, which combines a multivitamin, creatine, and TMG.

#supplement

Evaluate cholesterol-lowering mechanisms for dementia risk reduction

The mechanism used to lower LDL cholesterol might be as important as the lowering itself, as powerful PCSK9 inhibitors showed no clear dementia risk reduction in one study.