Fix What’s Making You Feel Old—From Joints to Mitochondria | Dr. Greg Kelly
Dave Asprey
Jun 27, 2025
Mindsip insights from this episode:
Address gut issues to prevent joint inflammation
The 'gut-joint axis' describes how gut problems like leaky gut allow bacterial toxins (LPS) to escape and directly cause inflammation in your joints.
Address insulin resistance in joints to manage blood sugar
Your joints can become insulin resistant and struggle to manage blood sugar, similar to how your brain can, which gets worse with age.
Utilize tamarind to alleviate oxalate-related joint pain
Tamarind, a key ingredient in the Tamaflex blend, may help break up the razor-sharp oxalate crystals that can form in joints and cause pain.
Consider sham knee surgery for effective pain relief
Studies show that sham knee surgery, where surgeons only cut the knee open and sew it back up, provides the same amount of pain reduction as an actual cartilage repair procedure.
Align daily activities with joints' circadian rhythm for optimal repair
Joints have their own body clock rhythm, where they tend to break down during daytime activity and rely on nighttime sleep to rebuild and repair.
Utilize undenatured collagen to signal self-repair in joints
Undenatured collagen, like that from eggshell membrane, works at very low doses by signaling the body through the gut-joint axis to repair its own collagen, rather than just providing raw building blocks.
Utilize cucumber extract to neutralize gut toxins and reduce inflammation
A special cucumber extract contains unique iminosugars that appear to neutralize the inflammatory impact of gut-derived bacterial toxins (LPS) on the joints.
Utilize L-Carnitine to fuel insulin-resistant joints
L-Carnitine can disproportionately help the joints of overweight people by helping them turn fats into fuel (ATP) when their joints have become insulin-resistant and can't use sugar effectively.
Avoid oral glucosamine for joint health if you have blood sugar issues
Oral glucosamine has poor bioavailability and competes with glucose for uptake into joint tissues, making it less effective for people with blood sugar regulation issues.
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