Hacking Oxytocin, How to Use Rapamycin, Level Up Your At-Home Cold Plunge, Curing Asperger’s & More! AMA #1 with Dave Asprey

Dave Asprey

Feb 27, 2025

Episode description

In this first-ever AMA episode, Dave tackles your biggest biohacking questions—straight from The Upgrade Collective! From optimizing brain power to pushing the limits of cold therapy, this episode is packed with cutting-edge hacks to supercharge your body and mind. If you’d like to have your questions answered on the next AMA, click the link below for details on The Upgrade Collective membership, and get all sorts of extra biohacking add-ons for your life!

In today’s episode: What if you could amplify oxytocin—the “love hormone”—to build stronger relationships and lower stress? Or upgrade your cold plunge routine for max benefits in less time? Dave reveals the science behind these powerful biohacks, plus his take on rapamycin for longevity, the right way to supplement for thyroid health (without a prescription), and even how he personally overcame Asperger’s traits through neuroplasticity and mitochondrial upgrades. There’s even some great advice for all the parents out there!

What You’ll Learn:

• How to naturally boost oxytocin for better relationships and emotional health

• The fastest way to upgrade your cold plunge for heat shock benefits

• Is rapamycin really a longevity miracle? Dave’s personal take

• How mitochondria impact brain power, mood, and aging—and how to fix them today!

• The shocking reason some people can’t process reality correctly (and how to retrain your brain)

• The real truth about stem cells, exosomes, and V-cells for regeneration

• The hidden dangers of selenium, thyroid supplements, and over-fasting

Mindsip insights from this episode:

Apply rapamycin topically for skin benefits

Instead of taking the pharmaceutical rapamycin orally, consider using it topically for skin benefits and using supplemental senolytics for internal effects.

#rapamycin

#skin

Apply stressors rapidly for greater biological impact

The speed at which a stressor like heat is applied and removed drives more significant biological change than a slow, gradual increase.

#hormesis

#stress

Bypass hot tub limit for enhanced heat shock response

You can bypass the 104°F legal limit on new hot tubs with an external heater to achieve a faster and more effective heat shock response at 107°F.

#biohacking

#hormesis

Reset body temperature with T3 thyroid hormone therapy

A chronically low body temperature can be reset by taking T3 thyroid hormone and keeping your body temperature above 102°F for a week.

#body-temperature

#thyroid

Legally import 90-day supply of non-scheduled prescriptions online

US law allows you to import a 90-day supply of many non-scheduled prescription drugs for personal use from online pharmacies.

#risk

Transform low energy brain into a superpower for pattern recognition

A brain that developed with low energy learns highly efficient processing, which can become a superpower for pattern recognition once mitochondrial function is restored.

#cognition

#mitochondria

Transform flashbacks into healing opportunities

Sudden negative flashbacks are a gift from your body's threat detection system, replaying an old trauma to give you an opportunity to heal it.

#healing

#trauma

Reconsider kale's superfood status due to oxalate concerns

Kale's popularity was driven by a PR firm, and it is high in oxalates which can deplete minerals and form harmful crystals in your body.

#nutrition

#oxalate

Utilize TUDCA for advanced liver healing

For liver healing, you can take 350 to 750 milligrams of synthesized TUDCA, a compound originally derived from bear gallbladders.

#liver

#supplement

Dave Asprey

Who Should Take Herbal Ecstasy Supplements? (The Billion-Dollar Backstory)

Boost Brain Power by 25% WITHOUT a Pill (Brain Optimization Secrets)

The Biohacking Tool That Will Change the World (Mitochondrial Transfusions)

The Fastest-Acting Nootropic I’ve Ever Used

Why Big Pharma Hates Nitric Oxide (And How to Use It Anyway)

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