I Did Mushrooms for Science, Pt. 1
Bryan Johnson
Mar 19, 2026
Episode description
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Mindsip insights from this episode:
Utilize Kernel Flow to measure brain activity during psychedelics
A wearable, helmet-like brain scanner called Kernel Flow is being used to measure brain activity changes resulting from the psychedelic experience.
Recognize full mushroom benefits beyond psilocybin
The full effects of magic mushrooms may come from a synergistic interaction between all their alkaloids, not just the psilocybin.
Track biomarkers for a measured psychedelic experience
The speaker is attempting the most measured psychedelic trip in history by tracking 249 biomarkers before and after taking five grams of magic mushrooms.
Beware ambition loss from high-dose psychedelics
A notable risk of high-dose psychedelics for driven people is that they might lose their ambition and desire to pursue their previous goals.
Utilize psychedelics to promote longevity by fixing systems
The speaker's philosophy is that psychedelics may promote longevity by fixing broken systems, not by making things biologically younger.
Investigate psychedelics' cellular effects on health
This experiment was inspired by recent scientific evidence showing psychedelics have interesting effects on both mouse and human cells.
Reframe psychedelics as potential longevity interventions
A core idea of the experiment is to shift the perception of psychedelics from just a mental health tool to a potential longevity intervention.
