Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse
Andrew Huberman
Mar 10, 2025
Mindsip insights from this episode:
Beware caffeine variability in Starbucks drinks
A study at the University of Florida found a three-fold difference in the caffeine content of the exact same Starbucks drink purchased on different days.
Leverage interest-driven focus in ADHD for task engagement
The ADHD brain is described as an interest-driven brain, in contrast to a non-ADHD brain which is importance-driven, explaining the difficulty with boring but necessary tasks.
Address ADHD to improve life expectancy by 10 years
A child diagnosed with ADHD has a life expectancy that is approximately 10 years shorter than their non-ADHD peers, a reduction on par with diabetes or major depression.
Address daytime arousal to resolve insomnia issues
For at least 90% of people with insomnia, the issue is not a faulty sleep system but rather the failure of the daytime arousal system to shut off properly at night.
Test and regulate circadian rhythm to address ADHD symptoms
An intriguing idea is that ADHD and other focus deficits may be the consequence of a misregulated circadian rhythm, which can be tested and potentially fixed.
Practice cyclic sighing to reduce nighttime urination
Dr. Cruise shares his personal experience that doing five minutes of cyclic sighing before bed almost completely eliminated his need to wake up during the night to urinate.
Normalize addiction risk in kids with ADHD through stimulant medications
Counterintuitively, putting children with ADHD on stimulant medications has been shown to normalize their risk of developing substance abuse problems later in life.
Experience smooth effects with Vyvanse for ADHD management
The ADHD medication Vyvanse is a pro-drug activated by red blood cells, resulting in a slow, even release that users often describe as 'smooth' and less jarring than other stimulants.
Recognize amphetamine psychosis risk with ADHD medications
Amphetamine-based ADHD drugs like Adderall carry a 1-in-500 risk of inducing a psychosis that can continue for weeks or months even after stopping the medication.
Boost cognition with Modafinil beyond motivation
A sophisticated study suggests that Modafinil may directly boost cognitive functions, whereas the benefits of amphetamines may come more from boosting motivation.
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