Jeff Bland (Part 2): The Science of Immune Aging—and How to Reverse It
Mark Hyman
Jun 4, 2025
Mindsip insights from this episode:
Reframe autoimmune disease as a sign of a strong immune response
Autoimmune disease in women may not be a sign of a weak immune system, but a highly adept one that's over-responding to environmental threats.
Differentiate between friendly and angry fat for better health understanding
There are two types of obesity: 'friendly fat' which is metabolically healthy, and 'angry fat' which is driven by an inflamed immune system and produces inflammatory markers.
Calculate Immune Inflammatory Index to assess inflammation
The Immune Inflammatory Index, a simple calculation using values from a standard blood count, can reveal your body's inflammatory state.
Measure immune age to predict longevity
The single best predictor of your year of death is the biological age of your immune system, which can be measured through epigenetic testing.
Reverse immune aging with Himalayan Tartary Buckwheat in 90 days
A pilot study showed that consuming Himalayan Tartary Buckwheat polyphenols daily for 90 days reduced the rate of immune cell aging by 47%.
Utilize simple tests to assess immune health
You can infer your immune health using readily available tests like a Complete Blood Count (CBC), hs-CRP, and Secretory IgA, which correlate well with complex epigenetic testing.
Utilize plant compounds to regulate gene expression
Plant compounds like flavonoids are not just simple antioxidants but are precise, cell-specific regulators of gene expression patterns.
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