Longevity Expert: "If You Avoid This, You're Protected From Brain Decline, Disease & Inflammation"

Rangan Chatterjee

Jun 13, 2025

Episode description

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What do obesity, insulin resistance, diabetes, fatty liver disease, hypertension, cardiovascular disease, stroke and dementia have in common? They are all chronic diseases that together are the leading cause of death in the world today. And they’re largely caused not by genes, but by our environment, lifestyle and food choices.

This much many of us already know. But today’s guest brings some valuable new information to the table: the role of uric acid. Dr David Perlmutter is a board-certified neurologist and six-time New York Times bestselling author, whose work has won him many high-profile awards. .

His latest book, Drop Acid: The Surprising New Science of Uric Acid, focuses on the pivotal role of uric acid in chronic metabolic diseases, claiming that lowering its level in the body holds the key to losing weight, controlling blood sugar, and transforming health.

#feelbetterlivemore #feelbetterlivemorepodcast

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Episode description

Mindsip insights from this episode:

Recognize food as a survival signal to avoid scarcity mindset

Food acts as an informational cue that can mistakenly tell our bodies to prepare for a winter of scarcity that never arrives.

#nutrition

Monitor blood sugar levels to protect brain health

Threats to your brain health begin at a blood sugar level of 105, a value far lower than the official cutoff for a diabetes diagnosis.

#cognition

#glucose

Aim for optimal health values to prevent risks

Significant health risks begin at lab values still considered 'normal,' such as a uric acid level above 5.5 mg/dL, long before symptoms like gout appear.

#risk

#uric-acid

Address elevated uric acid to combat metabolic issues

Recent research reveals elevated uric acid is not just correlated with metabolic problems but is a central, causative player in driving them.

#metabolism

#uric-acid

Reduce inflammation to enhance decision-making and empathy

Inflammation from a poor diet can sever the connection to your brain's prefrontal cortex, making you more impulsive and less empathetic.

#decision-making

#inflammation

Limit fructose intake to prevent liver overload

The small intestine can only process about five grams of fructose at once, with any excess overwhelming the liver and triggering fat production.

#fructose

#liver

Limit fructose to prevent fat storage and metabolic issues

Fructose is metabolized into uric acid, which acts as a switch that tells the body to increase fat storage, raise blood sugar, and elevate blood pressure.