Neuroscience Experts: Understand Your Brain For Optimal Health

Rich Roll

Aug 28, 2025

Episode description

Dr. Andrew Huberman, Drs. Ayesha and Dean Sherzai, Dr. Anna Lembke, Dr. Lisa Miller, and Dr. David Spiegel are leading researchers exploring the mysteries of the human brain. We discuss neuroplasticity, Alzheimer's prevention, addiction's neurochemistry, spiritual awareness, hypnosis, and more. READ MORE👉 http://bit.ly/richroll932
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CHAPTERS
00:00:00 INTRO
00:00:54 DR. ANDREW HUBERMAN
00:16:32 AD BREAK 1
00:19:13 DRS. AYESHA & DEAN SHERZAI On Fighting Cognitive Decline
00:33:58 DR. ANNA LEMBKE On The Neurochemistry of Addiction
00:43:54 AD BREAK 2
00:46:34 DR. LISA MILLER On The Neuroscience of Spirituality
01:02:37 DR. DAVID SPIEGEL On The Neuroscience of Hypnosis

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Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
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Mindsip insights from this episode:

Activate bonding and awareness through spiritual experiences

FMRI studies show that spiritual experiences quiet the brain's default mode network (rumination) and activate networks associated with bonding, orientation, and broad awareness.

#brain

#spirituality

Calm your mind by utilizing hypnosis to reduce salience network activity

Hypnosis works by turning down activity in the brain's 'salience network,' the part that acts as a context detector and decides what you should pay attention to.

#cognition

#hypnosis

Explore genetic link between hypnotizability and dopamine metabolism

High hypnotizability is associated with a specific genetic variation in the COMT enzyme, which affects how the brain metabolizes dopamine.

#dopamine

#genetics

Align internal pace with external world to overcome impatience

The feeling of impatience arises when your internal metronome, or the perceived speed of your bodily processes, is not matched to the pace of the external world.

#emotion

#mind

Harness focus to trigger neuroplasticity and enhance brain change

Neuroplasticity in adults is triggered by intense focus, which marks neurons for change, but the actual rewiring occurs during subsequent periods of deep rest and sleep.

#focus

#neuroplasticity

Control Alzheimer's risk through lifestyle choices

Only up to 3% of Alzheimer's cases are 100% driven by genes, while the other 97% are influenced by risk genes that can be controlled by lifestyle.

#Alzheimer's

#genetics

Prioritize vascular health to protect brain function

Vascular problems can predate Alzheimer's pathology by 20 years, meaning brain health is fundamentally about maintaining the health of its 400 miles of blood vessels.

#Alzheimer's

#vascular

Restore pleasure-pain balance to combat addiction

Addiction creates a dopamine deficit state where the brain's pleasure-pain balance is chronically tilted to the side of pain, requiring drug use just to feel normal.