Prevention Strategies for Neurodegenerative Diseases

Mark Hyman

May 20, 2024

Episode description

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Lifestyle and dietary factors are widely accepted as key drivers of disease among cardiologists, oncologists, and endocrinologists, however the impact of diet and lifestyle on our brain health still remains largely on the margins. And, while there are certainly other factors, creating healthy daily habits can make a significant difference.

In this episode, Dr. Hyman speaks with Dr. Marwan Sabbagh, Dr. Richard Isaacson, and Dr. Jay Lombard about the role of genetics in brain disorders, lifestyle habits you can start right now to reduce your risk or reverse symptoms, and why we need to look at bacteria as a cause of neurodegenerative disease.

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Mindsip insights from this episode:

Reconsider amyloid plaque as bacterial protective biofilm in Alzheimer's

The amyloid plaque seen in Alzheimer's may actually be a protective 'bomb shelter' or biofilm created by bacteria to shield themselves.

#Alzheimer's

#biofilm

Utilize hyperthermia to halt or reverse ALS progression

Hyperthermia, or inducing a controlled fever, is a therapy showing early promise in stopping or even reversing the progression of ALS in some patients.

#therapy

Reframe Alzheimer's as a systemic disease affecting the brain

The emerging paradigm is that Alzheimer's is not a primary brain disease but rather a systemic disease that affects the brain.

#Alzheimer's

#chronic-disease

Incorporate HIIT for ApoE4 gene carriers

High-Intensity Interval Training (HIIT) is considered almost necessary for individuals who carry at least one copy of the ApoE4 gene variant.

#APOE4

#HIIT

Implement ketogenic diet for symptomatic Alzheimer's management

A ketogenic diet makes more sense as a therapeutic intervention in the symptomatic phase of Alzheimer's, whereas a Mediterranean diet is better for prevention.

#Alzheimer's

#keto

Recognize brain insulin resistance as Type 3 diabetes

You can have insulin resistance in the brain, leading to what's called 'Type 3 diabetes', even if you don't have insulin resistance in the rest of your body.

#diabetes

#insulin

Identify oral bacteria as potential Alzheimer's trigger

A specific oral bacteria, P. gingivalis, creates a protein called gingipain that may be a neurotoxin and a trigger for neuroinflammation.

#Alzheimer's

#bacteria

Run to boost Brain-Derived Neurotrophic Factor for brain health

Many neuroscientists are runners because it is the fastest way to raise Brain-Derived Neurotrophic Factor (BDNF), which is described as 'Miracle-Gro for the brain'.