The 2 Week Glycine Experiment that Recovers Liver Health

Physionic

Mar 19, 2026

Episode description

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0:00 - Introduction
0:35 - Sinister Disappearance of Glycine
3:25 - My Poor Liver
4:26 - The 2 Week Experiment

Glycine on Cancer: https://www.youtube.com/watch?v=0nP8gH_zjnY
Glycine on Longevity: https://www.youtube.com/watch?v=3Y5QtNpYWMQ&t=312s
Glycine Deficiency and Disease: https://www.youtube.com/watch?v=jXIdxYUnTvI
Glycine on Sleep: https://www.youtube.com/watch?v=HxZl9LPV_7Q

References
[Study 665] Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, et al. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Sci Transl Med. 2020;12:eaaz2841. doi:10.1126/scitranslmed.aaz2841.

Funding/Conflict: This study was supported by U.S. National Institutes of Health grants HL150233, HL123333, HL138139, DK106540, HL137214, HL068878, and HL134569; the Michigan-Israel Partnership for Research and Education; the Israeli Centers of Research Excellence (I-CORE) program; and the Israel Science Foundation grant 824/19. Non-Profit Funding: The study also received support from the American Heart Association through Postdoctoral Fellowship 19POST34380224. Industry Funding/Conflicts: No industry funding was explicitly listed in the funding statement, although the Michigan Center for Therapeutic Innovation was also acknowledged as support; for conflicts of interest, O.R., Y.Z., J.Z., and Y.E.C. filed a patent application related to this work, and Y.E.C. is the founder of Diapin Therapeutics, which provided DT-109/110 for the study, while all other authors declared no competing interests.

[Study 666] Tan HC, Hsu JW, Tai ES, Chacko S, Wu V, Yen PM, et al. Metabolic impact of dietary glycine supplementation in individuals with severe obesity. Sci Rep. 2025;15:36433. doi:10.1038/s41598-025-20511-x.

Funding/Conflict: This study was supported by the Khoo Mentored Research Grant (Duke-NUS KMRA 2020/0013). Non-Profit Funding: No non-profit funding was explicitly listed. Industry Funding/Conflicts: No industry funding was explicitly listed, and the authors declared no competing interests.

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Enhance liver health with glycine supplementation

A recent human study showed that just two weeks of glycine supplementation significantly improved liver health, independent of any fat loss.

Supplement glycine during periods of poor health

The non-essential amino acid glycine may become essential to supplement during periods of poor health, as the body's natural stores can become drained.

Address glycine depletion in fatty liver disease

In conditions like fatty liver disease, the body not only produces less glycine but also has more active enzymes that break it down, further depleting the pool.

Utilize high dose glycine to enhance liver health

The dose used in the study to improve liver health was very high, at around 100 milligrams per kilogram of body weight.

Test glycine supplementation effects on liver markers

You could run a personal experiment by measuring your liver markers (AST and ALT) before and after two weeks of glycine supplementation to see its effect.

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