
The 2 Week Glycine Experiment that Recovers Liver Health
Physionic
Mar 19, 2026
Episode description
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0:00 - Introduction
0:35 - Sinister Disappearance of Glycine
3:25 - My Poor Liver
4:26 - The 2 Week Experiment
Glycine on Cancer: https://www.youtube.com/watch?v=0nP8gH_zjnY
Glycine on Longevity: https://www.youtube.com/watch?v=3Y5QtNpYWMQ&t=312s
Glycine Deficiency and Disease: https://www.youtube.com/watch?v=jXIdxYUnTvI
Glycine on Sleep: https://www.youtube.com/watch?v=HxZl9LPV_7Q
References
[Study 665] Rom O, Liu Y, Liu Z, Zhao Y, Wu J, Ghrayeb A, et al. Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome. Sci Transl Med. 2020;12:eaaz2841. doi:10.1126/scitranslmed.aaz2841.
Funding/Conflict: This study was supported by U.S. National Institutes of Health grants HL150233, HL123333, HL138139, DK106540, HL137214, HL068878, and HL134569; the Michigan-Israel Partnership for Research and Education; the Israeli Centers of Research Excellence (I-CORE) program; and the Israel Science Foundation grant 824/19. Non-Profit Funding: The study also received support from the American Heart Association through Postdoctoral Fellowship 19POST34380224. Industry Funding/Conflicts: No industry funding was explicitly listed in the funding statement, although the Michigan Center for Therapeutic Innovation was also acknowledged as support; for conflicts of interest, O.R., Y.Z., J.Z., and Y.E.C. filed a patent application related to this work, and Y.E.C. is the founder of Diapin Therapeutics, which provided DT-109/110 for the study, while all other authors declared no competing interests.
[Study 666] Tan HC, Hsu JW, Tai ES, Chacko S, Wu V, Yen PM, et al. Metabolic impact of dietary glycine supplementation in individuals with severe obesity. Sci Rep. 2025;15:36433. doi:10.1038/s41598-025-20511-x.
Funding/Conflict: This study was supported by the Khoo Mentored Research Grant (Duke-NUS KMRA 2020/0013). Non-Profit Funding: No non-profit funding was explicitly listed. Industry Funding/Conflicts: No industry funding was explicitly listed, and the authors declared no competing interests.
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