This Amino Acid was Accidentally Found to Improve Our Sleep
Brad Stanfield
Aug 11, 2025
Episode description
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Timestamps:
0:00 The accident that put glycine on the sleep map
1:15 Glycine's mechanism for improving sleep
1:47 Glycine human trial results
3:43 Dose
4:15 Glycine's impact on metabolic health
6:28 Four additional strategies for deep sleep
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Here are the links to the research papers referenced in the video:
https://www.sciencedirect.com/science/article/pii/S1347861319305729
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1479-8425.2006.00193.x
https://pmc.ncbi.nlm.nih.gov/articles/PMC3328957/
https://www.degruyterbrill.com/document/doi/10.1515/jcim-2020-0282/html
https://pubmed.ncbi.nlm.nih.gov/11456285/
https://pubmed.ncbi.nlm.nih.gov/24144057/
https://pmc.ncbi.nlm.nih.gov/articles/PMC10379184/
https://pubmed.ncbi.nlm.nih.gov/14732596/
https://pmc.ncbi.nlm.nih.gov/articles/PMC6516426/
https://journals.sagepub.com/doi/10.1177/0748730402239679
https://pmc.ncbi.nlm.nih.gov/articles/PMC6751071/
https://pubmed.ncbi.nlm.nih.gov/36870101/
https://www.mdpi.com/2674-0311/2/2/11
https://www.sciencedirect.com/science/article/abs/pii/S0022395619309872?via%3Dihub
https://pubmed.ncbi.nlm.nih.gov/33417003/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4138917
https://pubmed.ncbi.nlm.nih.gov/10883420/
https://pubmed.ncbi.nlm.nih.gov/38817505/
Thumbnail by James Kelly
Video edited by Troy Young
Script by John Milliken
The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.
Mindsip insights from this episode:
Implement strict four-hour caffeine window for better sleep
To ensure caffeine is cleared from your system by bedtime, one speaker restricts all caffeine intake to within the first four hours of waking up.
Rethink melatonin dosage for optimal results
Many over-the-counter melatonin supplements are excessively high, while a dose of just 300 micrograms is enough to match the body's natural production.
Take 3,000 milligrams of glycine before bed for better sleep quality
Studies showing improved sleep quality used a dose of about 3,000 milligrams of glycine taken shortly before bedtime.
Improve sleep quality with glycine for a refreshed morning
Unlike many sleep medications that can make you feel groggy, glycine improves sleep quality without disrupting the natural stages of sleep.
Utilize glycine supplements to combat metabolic syndrome
In a three-month study, glycine supplements reduced oxidative stress and lowered blood pressure in men with metabolic syndrome.
Leverage glycine to enhance sleep quality
Glycine's ability to improve sleep was discovered by accident when it was used as a supposedly neutral placebo in scientific studies.
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