The King of Protein, Whey, Finally Defeated by a Newcomer?

Physionic

Jan 1, 2026

Episode description

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HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

JOIN THE COMMUNITY
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Created with Biorender

0:00 - Introduction
0:47 - A New Player in Town
1:52 - More Leucine, More Muscle
4:00 - Muscle Synthesis
4:45 - The Hypothesis - BLG Advantage, yet?
8:30 - Is Whey's throne toppled?

References [Funding/Conflicts of Interest are available in the free article supplied to the email list and/or the free Physionic Community - both linked above]

[569] Hostrup M, Lundgren E. β-Lactoglobulin: a novel bioactive whey protein with incretin-modulating and muscle anabolic properties. J Nutr Physiol. 2025;3:100007. doi:10.1016/j.jnphys.2025.100007

[570] Ely IA, Paul M, Wall JJS, et al. The Effect of Leucine-Enriched ẞ-Lactoglobulin Versus an Isonitrogenous Whey Protein Isolate on Skeletal Muscle Protein Anabolism in Young Healthy Males. Nutrients. 2025;17(21):3410. doi:10.3390/nu17213410

[571] Rogers LM, Quinlan JI, Lau K, Belfield AE, Korzepa M, Hannaian SJ, et al. Postprandial Bioavailability and Efficacy of Recombinant Bovine ẞ-lactoglobulin for Resistance Training-Induced Skeletal Muscle Adaptation in Young Adults. Med Sci Sports Exerc. 2025. doi:10.1249/MSS.0000000000003756

[572] Mose M, Møller N, Jessen N, et al. β-Lactoglobulin Is Insulinotropic Compared with Casein and Whey Protein Ingestion during Catabolic Conditions in Men in a Double-Blinded Randomized Crossover Trial. J Nutr. 2021;151(6):1462-1472. doi:10.1093/jn/nxab010

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#wheyprotein #wheyproteinreview #musclebuilding

Episode description

JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

HEALTH AUTONOMY [COURSE]
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

JOIN THE COMMUNITY
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

EMAIL LIST
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

HIRE ME FOR CONSULTING:
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:47 - A New Player in Town
1:52 - More Leucine, More Muscle
4:00 - Muscle Synthesis
4:45 - The Hypothesis - BLG Advantage, yet?
8:30 - Is Whey's throne toppled?

References [Funding/Conflicts of Interest are available in the free article supplied to the email list and/or the free Physionic Community - both linked above]

[569] Hostrup M, Lundgren E. β-Lactoglobulin: a novel bioactive whey protein with incretin-modulating and muscle anabolic properties. J Nutr Physiol. 2025;3:100007. doi:10.1016/j.jnphys.2025.100007

[570] Ely IA, Paul M, Wall JJS, et al. The Effect of Leucine-Enriched ẞ-Lactoglobulin Versus an Isonitrogenous Whey Protein Isolate on Skeletal Muscle Protein Anabolism in Young Healthy Males. Nutrients. 2025;17(21):3410. doi:10.3390/nu17213410

[571] Rogers LM, Quinlan JI, Lau K, Belfield AE, Korzepa M, Hannaian SJ, et al. Postprandial Bioavailability and Efficacy of Recombinant Bovine ẞ-lactoglobulin for Resistance Training-Induced Skeletal Muscle Adaptation in Young Adults. Med Sci Sports Exerc. 2025. doi:10.1249/MSS.0000000000003756

[572] Mose M, Møller N, Jessen N, et al. β-Lactoglobulin Is Insulinotropic Compared with Casein and Whey Protein Ingestion during Catabolic Conditions in Men in a Double-Blinded Randomized Crossover Trial. J Nutr. 2021;151(6):1462-1472. doi:10.1093/jn/nxab010

CRITIQUES, RULES, AND NOTES

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#wheyprotein #wheyproteinreview #musclebuilding

Mindsip insights from this episode:

Choose whey protein for optimal muscle growth

For most people, whey protein is still the best choice as the extra leucine from more expensive BLG likely provides no real-world value for muscle growth.

Increase leucine intake to boost muscle protein synthesis in older adults

Older people are less sensitive to leucine and require a higher dose to achieve the same muscle protein synthesis response as younger people.

Consider BLG protein for optimal health in older adults

The speaker hypothesizes that BLG protein may be superior to whey specifically for people over 60, who could benefit from its higher leucine content.

Understand leucine threshold to optimize muscle protein synthesis

Muscle protein synthesis has a 'leucine threshold,' meaning you need a minimum amount to stimulate it, but consuming more beyond a certain ceiling provides no extra benefit.

Challenge whey protein with beta-lactoglobulin for superior benefits

A protein called beta-lactoglobulin (BLG), which is an even purer form extracted from whey, is challenging whey protein's dominance.

Prioritize whey over BLG for optimal muscle growth

Despite BLG delivering more of the amino acid leucine into the blood, studies show it does not lead to greater muscle growth or strength compared to whey in young individuals.

Increase whey protein to combat leucine resistance in seniors

Instead of switching to BLG, older adults looking to overcome leucine resistance could simply increase their whey protein consumption.

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