The King of Protein, Whey, Finally Defeated by a Newcomer?

Physionic

Jan 1, 2026

Episode description

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0:00 - Introduction
0:47 - A New Player in Town
1:52 - More Leucine, More Muscle
4:00 - Muscle Synthesis
4:45 - The Hypothesis - BLG Advantage, yet?
8:30 - Is Whey's throne toppled?

References [Funding/Conflicts of Interest are available in the free article supplied to the email list and/or the free Physionic Community - both linked above]

[569] Hostrup M, Lundgren E. β-Lactoglobulin: a novel bioactive whey protein with incretin-modulating and muscle anabolic properties. J Nutr Physiol. 2025;3:100007. doi:10.1016/j.jnphys.2025.100007

[570] Ely IA, Paul M, Wall JJS, et al. The Effect of Leucine-Enriched ẞ-Lactoglobulin Versus an Isonitrogenous Whey Protein Isolate on Skeletal Muscle Protein Anabolism in Young Healthy Males. Nutrients. 2025;17(21):3410. doi:10.3390/nu17213410

[571] Rogers LM, Quinlan JI, Lau K, Belfield AE, Korzepa M, Hannaian SJ, et al. Postprandial Bioavailability and Efficacy of Recombinant Bovine ẞ-lactoglobulin for Resistance Training-Induced Skeletal Muscle Adaptation in Young Adults. Med Sci Sports Exerc. 2025. doi:10.1249/MSS.0000000000003756

[572] Mose M, Møller N, Jessen N, et al. β-Lactoglobulin Is Insulinotropic Compared with Casein and Whey Protein Ingestion during Catabolic Conditions in Men in a Double-Blinded Randomized Crossover Trial. J Nutr. 2021;151(6):1462-1472. doi:10.1093/jn/nxab010

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#wheyprotein #wheyproteinreview #musclebuilding

Mindsip insights from this episode:

Choose whey protein for optimal muscle growth

For most people, whey protein is still the best choice as the extra leucine from more expensive BLG likely provides no real-world value for muscle growth.

#muscle

#protein

Increase leucine intake to boost muscle protein synthesis in older adults

Older people are less sensitive to leucine and require a higher dose to achieve the same muscle protein synthesis response as younger people.

#leucine

#muscle

Consider BLG protein for optimal health in older adults

The speaker hypothesizes that BLG protein may be superior to whey specifically for people over 60, who could benefit from its higher leucine content.

#leucine

#protein

Understand leucine threshold to optimize muscle protein synthesis

Muscle protein synthesis has a 'leucine threshold,' meaning you need a minimum amount to stimulate it, but consuming more beyond a certain ceiling provides no extra benefit.

#leucine

#muscle

Challenge whey protein with beta-lactoglobulin for superior benefits

A protein called beta-lactoglobulin (BLG), which is an even purer form extracted from whey, is challenging whey protein's dominance.

#protein

Prioritize whey over BLG for optimal muscle growth

Despite BLG delivering more of the amino acid leucine into the blood, studies show it does not lead to greater muscle growth or strength compared to whey in young individuals.