Are You Nutrient Deficient? The Hidden Factors of Accelerated Aging | Rhonda Patrick - ENCORE

Mark Hyman

Dec 31, 2025

Episode description

This week, in another holiday edition of The Dr. Hyman Show, I’m highlighting a conversation with Dr. Rhonda Patrick, a leading expert in nutritional science and aging — a discussion that still feels incredibly important today. We dig into how hidden micronutrient deficiencies can influence metabolism, mood, longevity, and long-term health. Here’s to supporting our health in the year ahead.

In this episode, you’ll learn:

• Why vitamin D is essential for longevity, immune health, and mood

• How magnesium influences metabolism, blood sugar, and brain function

• Why even “healthy” diets can leave us undernourished

• What it takes to test and personalize your micronutrient intake

Better aging starts by giving your cells what they’re missing. When your body has the right nutrients, it can repair, renew, and thrive at any stage of life.

Here’s to a healthy start to the new year — I’m excited for what we’ll explore together.

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Mindsip insights from this episode:

Choose Avmacol for effective sulforaphane conversion

Dr. Patrick recommends a supplement called Avmacol because it contains a stabilized myrosinase enzyme, which is critical for converting the precursor into active sulforaphane.

#sulforaphane

#supplement

Prioritize micronutrients for long-term health over immediate survival

Your body prioritizes using scarce micronutrients for immediate survival functions, like blood clotting, at the expense of long-term health functions like DNA repair.

#nutrition

Incorporate essential supplements for optimal health

A recommended daily supplement stack includes 4,000 IUs of Vitamin D, 2 grams of Omega-3s (EPA/DHA), a high-quality multivitamin, and a bioavailable magnesium salt.

#supplement

#vitamin-D

Reverse brain aging with daily multivitamin intake

The recent COSMOS trial showed that older adults taking a daily multivitamin experienced an improvement equivalent to reversing two years of brain aging.

#cognition

#supplement

Prioritize magnesium for DNA repair and long-term health

When magnesium is insufficient, your body uses it for essential ATP energy production but neglects to use it for DNA repair enzymes, which can lead to damage over time.

#longevity

#magnesium

Maintain omega-3 levels to reduce mortality risk

Having a low omega-3 index (below 4%) was found to carry the same mortality risk as being a smoker.

#mortality

#omega-3

Protect developing fetus from mercury with omega-3 intake

Studies found that omega-3 fatty acids can protect a developing fetus from potential mercury toxicity, with children of mothers with high omega-3 and high mercury scoring higher on IQ tests.