Too much Talk - What does the Science ACTUALLY say?

Physionic

Jun 2, 2025

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:56 - Methylene Blue Study
1:31 - Fascinating Mechanisms of Methylene Blue
3:23 - What happens to the Brain?
7:17 - Dosing Methylene Blue & Caveats...
9:50 - Main Points

References
[Study 456] Rodriguez P, Zhou W, Barrett DW, et al. Multimodal randomized functional MR imaging of the effects of methylene blue in the human brain. Radiology. 2016;281(2):516–526. doi:10.1148/radiol.2016152893.

Funding/Conflicts: Mixed Funding [Public: National Center for Advancing Translational Sciences (UL1TR001120); Non-Profit: Julio C. Palmaz, MD, Endowment for Excellence in Radiology Research] // No direct Conflicts of Interest

[Study 457] Rojas JC, Bruchey AK, Gonzalez-Lima F. Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue. Prog Neurobiol. 2012;96(1):32-45. doi:10.1016/j.pneurobio.2011.10.007

Funding/Conflicts: Public Funding [Canadian Institutes of Health Research] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#methyleneblue

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:56 - Methylene Blue Study
1:31 - Fascinating Mechanisms of Methylene Blue
3:23 - What happens to the Brain?
7:17 - Dosing Methylene Blue & Caveats...
9:50 - Main Points

References
[Study 456] Rodriguez P, Zhou W, Barrett DW, et al. Multimodal randomized functional MR imaging of the effects of methylene blue in the human brain. Radiology. 2016;281(2):516–526. doi:10.1148/radiol.2016152893.

Funding/Conflicts: Mixed Funding [Public: National Center for Advancing Translational Sciences (UL1TR001120); Non-Profit: Julio C. Palmaz, MD, Endowment for Excellence in Radiology Research] // No direct Conflicts of Interest

[Study 457] Rojas JC, Bruchey AK, Gonzalez-Lima F. Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue. Prog Neurobiol. 2012;96(1):32-45. doi:10.1016/j.pneurobio.2011.10.007

Funding/Conflicts: Public Funding [Canadian Institutes of Health Research] // No direct Conflicts of Interest

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#methyleneblue

Mindsip insights from this episode:

Utilize methylene blue to enhance mitochondrial energy production

Methylene blue acts as an electron cycler, reducing damaging molecules and facilitating energy production by donating lost electrons back to the mitochondrial chain.

Increase brain activity with methylene blue supplementation

Functional MRI scans show that methylene blue increases brain activity, indicated by greater blood deoxygenation in certain brain regions compared to a placebo.

Clarify cognitive test results for methylene blue treatment

While one study showed cognitive improvement within the methylene blue group, there was no statistically significant difference between the methylene blue and placebo groups after treatment.

Understand critical dosing paradox of methylene blue

Methylene blue demonstrates a critical dosing paradox, as low doses can treat the condition methemoglobinemia, while high doses are known to cause it.

Evaluate mixed evidence of methylene blue for dementia treatment

Research on methylene blue for dementia has produced mixed results, with some trials showing no benefit at doses that were effective in other cognitive studies.

Understand methylene blue's side effect of staining tissues blue

A notable side effect of methylene blue is that it can physically stain tissues, including the tongue and even the brain, turning them blue.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius