
Too much Talk - What does the Science ACTUALLY say?
Physionic
Jun 2, 2025
Mindsip insights from this episode:
Utilize methylene blue to enhance mitochondrial energy production
Methylene blue acts as an electron cycler, reducing damaging molecules and facilitating energy production by donating lost electrons back to the mitochondrial chain.
Increase brain activity with methylene blue supplementation
Functional MRI scans show that methylene blue increases brain activity, indicated by greater blood deoxygenation in certain brain regions compared to a placebo.
Clarify cognitive test results for methylene blue treatment
While one study showed cognitive improvement within the methylene blue group, there was no statistically significant difference between the methylene blue and placebo groups after treatment.
Understand critical dosing paradox of methylene blue
Methylene blue demonstrates a critical dosing paradox, as low doses can treat the condition methemoglobinemia, while high doses are known to cause it.
Evaluate mixed evidence of methylene blue for dementia treatment
Research on methylene blue for dementia has produced mixed results, with some trials showing no benefit at doses that were effective in other cognitive studies.
Understand methylene blue's side effect of staining tissues blue
A notable side effect of methylene blue is that it can physically stain tissues, including the tongue and even the brain, turning them blue.
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