We’ve been lied to about Vitamin K

Physionic

Apr 6, 2026

Episode description

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0:00 - Introduction
0:58 - The Reality
1:38 - A Closer Look at Reversing Plaque
2:31 - Reversing Arterial Calcification
3:31 - Vitamin K and the Matrix Gla Protein - Reversing Calcification?
6:30 - Big Picture Hope: Cardiovascular Disease
10:53 - My Perspective

References*
**Funding/Conflicts/Full Citations are provided in the free article (found in email list and Physionic Community Article Library)

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[Study 681] doi:10.1007/s11255-019-02275-2

[Study 682] Kurnatowska I, et al. Effect of vitamin K2 substitution on the progression of atherosclerosis and calcification in nondialyzed patients with chronic kidney disease stages 3–5. Pol Arch Med Wewn. 2015;125(9):631-640.

[Study 683] doi:10.1681/ASN.2019060579

[Study 684] Fulton RL, McMurdo MET, Hill A, et al. Effect of vitamin K on vascular health and physical function in older people with vascular disease—a randomised controlled trial. J Nutr Health Aging. 2016;20(3):325-333.

[Study 690] doi:10.1016/j.jacadv.2023.100643

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

Mindsip insights from this episode:

Utilize 200-400 micrograms of vitamin K2 for effectiveness

In studies that did show a positive effect, the vitamin K2 doses most often used were around 200 to 400 micrograms per day.

#supplement

#vitamin-K

Leverage vitamin K2 for heart disease protection

Despite weaker evidence quality, multiple lines of data suggest vitamin K2 has an independent protective effect against heart disease, unlike vitamin K1.

#heart

#vitamin-K

Avoid vitamin K supplementation if using anticoagulants

Vitamin K supplementation can cause adverse reactions like bleeding events in people taking anticoagulant medications due to its role in the blood clotting cascade.

#supplement

#vitamin-K

Investigate vitamin K's paradox in arterial calcification reduction

Although vitamin K supplementation reliably activates the anti-calcification protein MGP, this does not consistently translate to a measured reduction in arterial calcification in studies.

#artery

#vitamin-K

Focus on K1-rich vegetables for heart health benefits

The heart-healthy relationship seen with vitamin K1 intake disappears when accounting for overall diet, suggesting the benefit comes from eating K1-rich vegetables, not the vitamin itself.

#vegetable

#vitamin-K

Question the effectiveness of vitamin K against arterial plaque and calcification

The majority of randomized controlled trials indicate that vitamin K is ineffective against both arterial plaque and arterial calcification.

#plaque

#vitamin-K

Investigate vitamin K benefits for individuals with pre-existing conditions

The few studies indicating a benefit from vitamin K were often conducted in people with pre-existing conditions like heart disease, kidney disease, or metabolic dysfunction.