Women's sexual health: desire, arousal, and orgasms, navigating perimenopause, and enhancing satisfaction | Sally Greenwald, M.D., M.P.H.
Peter Attia
Nov 3, 2025
Mindsip insights from this episode:
Implement three-step vaginal health routine for optimal care
Adopt a three-step vaginal health routine analogous to facial care: use lubricant like sunscreen, a vaginal moisturizer like face cream, and local hormones as a long-term health serum.
Choose silicone-based lubricants with optimal osmolality for vaginal health
Use silicone-based lubricants with an osmolality near 300, like Good Clean Love, as popular brands like KY or Astroglide can have an osmolality of 4,000-8,000, which dehydrates vaginal tissue.
Utilize vibrators to maintain orgasm as nerve fibers age
As women age, the nerve fibers responsive to light touch degrade, while myelinated fibers responsive to vibration and deep pressure remain, making vibrators an evidence-based tool for maintaining orgasm.
Recognize responsive desire in women to enhance intimacy
Unlike men who often have spontaneous desire, about 85% of women experience "responsive desire," meaning desire is triggered in response to arousal, not in anticipation of it.
Acknowledge need for external clitoral stimulation in 90% of women
It is completely normal for the 90% of women who cannot orgasm from penetrative intercourse alone to require external clitoral stimulation.
Utilize low-dose THC to enhance orgasm satisfaction and sex drive
A low dose of 1-2 milligrams of THC can significantly increase orgasm satisfaction and sex drive, whereas higher doses may be sedating and have an adverse effect.
Address sexual desire discordance to reduce divorce risk
The biggest risk factor for divorce is not the frequency of sex, but "sexual desire discordance," where one partner wants more sex than the other.
Determine ovulation preference to guide perimenopause hormone strategy
For perimenopausal women, the first question to determine hormone strategy is "do you like ovulating or not," which guides the choice between ovulation-suppressing contraception or non-suppressing MHT.
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