Cardiac Preconditioning: How to Use Mini Heart Attacks to protect against Heart Attacks

Physionic

22 ene 2025

Episode description

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0:00 - Introduction
0:35 - Ischemic Heart Attack
1:05 - The Impact of Cardiac Preconditioning
1:52 - Understanding Preconditioning
2:30 - How does Cardiac Preconditioning work?
4:26 - How to increase Cardiac Preconditioning?
5:49 - A Caveat...

References
[Study 390] Zaugg M, Lucchinetti E, Uecker M, Pasch T, Schaub MC. Anaesthetics and cardiac preconditioning. Part I. Signalling and cytoprotective mechanisms. Br J Anaesth. 2003;91(4):551-565. doi:10.1093/bja/aeg205

Funding/Conflicts: Non-Profit Funding [Swiss Society for Anaesthesiology and Perioperative Medicine; Swiss National Science Foundation; Hartmann-Miller Foundation; Swiss Heart Foundation] / Unknown Conflicts of Interest

[Study 391] Frasier CR, Moore RL, Brown DA. Exercise-induced cardiac preconditioning: how exercise protects your achy-breaky heart. J Appl Physiol (1985). 2011;111(3):905-915. doi:10.1152/japplphysiol.00004.2011

Funding/Conflicts: Unknown Funding / No Conflicts of Interest

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#hearthealthtips #hearthealthawareness

Episode description

Mindsip insights from this episode:

Utilize cardiac preconditioning to prevent major heart attacks

Cardiac preconditioning involves inducing short periods of ischemia, similar to a mini-heart attack, to create lasting protection against a future, major heart attack.

#adaptation

#heart

Exercise every other day for continuous heart protection

The heart conditioning effects from exercise can last up to 72 hours, meaning exercising every other day could provide constant protection.

#exercise

#heart

Utilize preconditioning within 40 minutes for maximum protection

The protective effect of preconditioning is time-sensitive; in one animal study, it significantly reduced damage within a 40-minute window but offered no protection after three hours.

#adaptation

Increase BCL2 protein to block heart cell death through preconditioning

One way preconditioning works is by increasing the BCL2 protein, which blocks a form of programmed cell death called apoptosis in heart muscle cells.

#heart

#regeneration

Implement cardiac preconditioning to reduce heart attack size by 40%

Cardiac preconditioning is a technique that can reduce the size of a future heart attack by 40% or more, which could be the difference between life and death.

#heart

#recovery

Induce cardiac preconditioning through aerobic endurance exercise

Aerobic endurance exercise, and possibly high-intensity interval training, is a practical way to induce cardiac preconditioning and its protective effects.