#1 LONGEVITY SCIENTIST Reveals The Optimal Diet & Fasting Window For Longevity | Valter Longo, Ph.D

Rich Roll

Feb 10, 2025

Episode description

Dr. Valter Longo, Director of USC's Longevity Institute and one of TIME's 50 most influential people in healthcare, reveals the mechanistic power of therapeutic fasting. We discuss his groundbreaking Fasting Mimicking Diet, its implications for cancer treatment, disease reversal, and extending human healthspan. READ MORE👉🏾 https://bit.ly/richroll889
✌🏼🌱 - Rich

This Episode Is Brought To You By…
Seed: Use code RICHROLL25 to get 25% off your first month 👉https://bit.ly/seedxrrp2025
Squarespace: Use code RichRoll to save 10% off 👉https://bit.ly/squarespace2025
BetterHelp: Use the code RICHROLL to get 10% off your first month 👉BetterHelp.com/richroll
On: High-performance shoes & apparel crafted for comfort and style 👉on.com/richroll

Check out all of the amazing discounts from our Sponsors 👉🏾 https://bit.ly/rrpsponsors

LISTEN / SUBSCRIBE TO THE PODCAST
Apple Podcasts: http://bit.ly/rrpitunes
Spotify: http://bit.ly/rrpspotify
Google: http://bit.ly/rrpgooglepods

Meal Planner: http://meals.richroll.com
Voicing Change Book: http://richroll.com/vc
Clips Channel: https://www.youtube.com/c/RichRollPodcastClips
Newsletter: http://bit.ly/rollcallemail

CHAPTERS
00:00:00 Intro
00:03:54 Funding for Research and Clinical Trials
00:05:29 Role of NIH in Research and Clinical Trials
00:06:45 Latest Findings on Fasting and Time-Restricted Eating
00:07:21 Efficacy of 12-Hour Fasting Window
00:10:31 Fasting-Mimicking Diet
00:11:54 Understanding Time-Restricted Eating
00:13:27 Impact of Eating Habits on Sleep
00:16:36 Exploration of Calorie Restriction and Fasting-Mimicking Diet
00:17:50 The Longevity Diet and Comparing Different Diets
00:18:29 Understanding the Impact of Individual Food Items
00:20:03 Role of Genetics in Diet and Aging
00:21:52 Potential of Fasting-Mimicking Diet in Disease Treatment
00:26:03 Understanding the Mechanisms of Fasting Diets
00:27:42 Metabolic Switches and Energy Modes
00:29:56 Challenges in Weight Loss and Energy Saving Mode
00:33:17 Ad Break
00:35:21 Role of Fasting-Mimicking Diet in Disease Reversal
00:36:06 Fasting-Mimicking Diet and Regeneration of Immune System
00:41:17 Applicability of Animal Studies to Human Biology
00:45:05 Receptivity of Traditional Medical Community to Fasting Diets
00:46:07 The Connection Between Aging and Chronic Diseases
00:47:51 Fasting-Mimicking Diet and Bone Density
00:48:10 Fasting-Mimicking Diet and Muscle Mass
00:49:50 Combining Fasting-Mimicking Diet with GLP-1
00:51:37 Combining Fasting-Mimicking Diet with Liraglutide
00:54:23 The Importance of Effort and Discomfort in Achieving Health Goals
00:58:28 The Growing Interest in Healthspan Extension and Longevity Medicine
00:59:44 The Role of Protein in the Longevity Diet
01:01:51 Understanding Protein Intake and Aging
01:03:30 Role of Amino Acids in Aging and Health
01:05:36 Impact of Protein Pathway on Aging
01:06:56 The Detrimental Effects of High Protein Diet
01:09:43 The Importance of Balanced Amino Acid Intake
01:11:17 Practical Implementation of Balanced Protein Intake
01:13:42 Ad Break
01:16:05 Discussion on Brian Johnson's Blueprint Protocol
01:18:27 Risks and Uncertainties of Unconventional Diets and Supplements
01:23:27 The Misconceptions of Short-Term Effects of Diets
01:26:17 The Role of Genetics in Diet and Longevity
01:27:59 The Complexity of Cancer and the Role of Fasting-Mimicking Diet
01:29:50 The Potential of Fasting-Mimicking Diet in Cancer Treatment
01:35:58 The Potential of Fasting-Mimicking Diet in Various Cancer Treatments
01:42:43 Mechanism of Fasting-Mimicking Diet in Cancer Treatment
01:45:39 The Message of the Book: Cancer Prevention and Treatment
01:47:29 The Role of AI in Identifying Escape Pathways and Drugs
01:49:18 Concerns and Potential Dangers of AI
01:51:30 The Need for Regulation of AI
01:54:30 Comparing AI with Nuclear Power

CONNECT WITH RICH
✩ Website - http://richroll.com​
✩ Rich Roll Podcast - https://richroll.com/all-episodes/
✩ Instagram - https://www.instagram.com/richroll/
✩ Twitter - https://twitter.com/richroll
✩ Facebook - https://www.facebook.com/richrollfans
✩ Strava - https://www.strava.com/athletes/14443?oq=rich
✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/finding-ultra/
✩ Meals - http://meals.richroll.com​
✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/the-plantpower-way-signed/
✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/the-plantpower-way-italia-signed/
✩ Support - https://www.patreon.com/richroll

FILMED AND EDITED BY DAN DRAKE
https://www.dandrake333.com/

* * * * *

NEW TO RICH?
Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
http://bit.ly/otillonyt
http://bit.ly/vegansglam

I LOVE MAIL! SEND IT HERE:
2630 Conejo Spectrum St.
Thousand Oaks, CA 91320

#richroll #richrollpodcast

Episode description

Dr. Valter Longo, Director of USC's Longevity Institute and one of TIME's 50 most influential people in healthcare, reveals the mechanistic power of therapeutic fasting. We discuss his groundbreaking Fasting Mimicking Diet, its implications for cancer treatment, disease reversal, and extending human healthspan. READ MORE👉🏾 https://bit.ly/richroll889
✌🏼🌱 - Rich

This Episode Is Brought To You By…
Seed: Use code RICHROLL25 to get 25% off your first month 👉https://bit.ly/seedxrrp2025
Squarespace: Use code RichRoll to save 10% off 👉https://bit.ly/squarespace2025
BetterHelp: Use the code RICHROLL to get 10% off your first month 👉BetterHelp.com/richroll
On: High-performance shoes & apparel crafted for comfort and style 👉on.com/richroll

Check out all of the amazing discounts from our Sponsors 👉🏾 https://bit.ly/rrpsponsors

LISTEN / SUBSCRIBE TO THE PODCAST
Apple Podcasts: http://bit.ly/rrpitunes
Spotify: http://bit.ly/rrpspotify
Google: http://bit.ly/rrpgooglepods

Meal Planner: http://meals.richroll.com
Voicing Change Book: http://richroll.com/vc
Clips Channel: https://www.youtube.com/c/RichRollPodcastClips
Newsletter: http://bit.ly/rollcallemail

CHAPTERS
00:00:00 Intro
00:03:54 Funding for Research and Clinical Trials
00:05:29 Role of NIH in Research and Clinical Trials
00:06:45 Latest Findings on Fasting and Time-Restricted Eating
00:07:21 Efficacy of 12-Hour Fasting Window
00:10:31 Fasting-Mimicking Diet
00:11:54 Understanding Time-Restricted Eating
00:13:27 Impact of Eating Habits on Sleep
00:16:36 Exploration of Calorie Restriction and Fasting-Mimicking Diet
00:17:50 The Longevity Diet and Comparing Different Diets
00:18:29 Understanding the Impact of Individual Food Items
00:20:03 Role of Genetics in Diet and Aging
00:21:52 Potential of Fasting-Mimicking Diet in Disease Treatment
00:26:03 Understanding the Mechanisms of Fasting Diets
00:27:42 Metabolic Switches and Energy Modes
00:29:56 Challenges in Weight Loss and Energy Saving Mode
00:33:17 Ad Break
00:35:21 Role of Fasting-Mimicking Diet in Disease Reversal
00:36:06 Fasting-Mimicking Diet and Regeneration of Immune System
00:41:17 Applicability of Animal Studies to Human Biology
00:45:05 Receptivity of Traditional Medical Community to Fasting Diets
00:46:07 The Connection Between Aging and Chronic Diseases
00:47:51 Fasting-Mimicking Diet and Bone Density
00:48:10 Fasting-Mimicking Diet and Muscle Mass
00:49:50 Combining Fasting-Mimicking Diet with GLP-1
00:51:37 Combining Fasting-Mimicking Diet with Liraglutide
00:54:23 The Importance of Effort and Discomfort in Achieving Health Goals
00:58:28 The Growing Interest in Healthspan Extension and Longevity Medicine
00:59:44 The Role of Protein in the Longevity Diet
01:01:51 Understanding Protein Intake and Aging
01:03:30 Role of Amino Acids in Aging and Health
01:05:36 Impact of Protein Pathway on Aging
01:06:56 The Detrimental Effects of High Protein Diet
01:09:43 The Importance of Balanced Amino Acid Intake
01:11:17 Practical Implementation of Balanced Protein Intake
01:13:42 Ad Break
01:16:05 Discussion on Brian Johnson's Blueprint Protocol
01:18:27 Risks and Uncertainties of Unconventional Diets and Supplements
01:23:27 The Misconceptions of Short-Term Effects of Diets
01:26:17 The Role of Genetics in Diet and Longevity
01:27:59 The Complexity of Cancer and the Role of Fasting-Mimicking Diet
01:29:50 The Potential of Fasting-Mimicking Diet in Cancer Treatment
01:35:58 The Potential of Fasting-Mimicking Diet in Various Cancer Treatments
01:42:43 Mechanism of Fasting-Mimicking Diet in Cancer Treatment
01:45:39 The Message of the Book: Cancer Prevention and Treatment
01:47:29 The Role of AI in Identifying Escape Pathways and Drugs
01:49:18 Concerns and Potential Dangers of AI
01:51:30 The Need for Regulation of AI
01:54:30 Comparing AI with Nuclear Power

CONNECT WITH RICH
✩ Website - http://richroll.com​
✩ Rich Roll Podcast - https://richroll.com/all-episodes/
✩ Instagram - https://www.instagram.com/richroll/
✩ Twitter - https://twitter.com/richroll
✩ Facebook - https://www.facebook.com/richrollfans
✩ Strava - https://www.strava.com/athletes/14443?oq=rich
✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/finding-ultra/
✩ Meals - http://meals.richroll.com​
✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/the-plantpower-way-signed/
✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/the-plantpower-way-italia-signed/
✩ Support - https://www.patreon.com/richroll

FILMED AND EDITED BY DAN DRAKE
https://www.dandrake333.com/

* * * * *

NEW TO RICH?
Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles:
http://bit.ly/otillonyt
http://bit.ly/vegansglam

I LOVE MAIL! SEND IT HERE:
2630 Conejo Spectrum St.
Thousand Oaks, CA 91320

#richroll #richrollpodcast

Mindsip insights from this episode:

Prioritize amino acid profiles over protein sources

The term 'protein' is almost irrelevant because the specific amino acid profile is what matters, which can differ by up to ten-fold between various sources.

Implement 12-hour eating window for effective time-restricted eating

A 12-hour eating and 12-hour fasting window is the safest, easiest, and most effective approach to daily time-restricted eating for the general population.

Incorporate Fasting Mimicking Diet to enhance cancer survival rates

In a study on women with metastatic triple-negative breast cancer, adding the Fasting Mimicking Diet to chemotherapy nearly doubled their overall survival.

Avoid extreme biohacking to prevent long-term health risks

Taking hundreds of supplements and following extreme eating windows is a huge gamble, as the complex interactions and unknown long-term effects could lead to a big, negative surprise 25 years later.

Adjust protein intake after age 65 for optimal health

Data suggests a low-protein diet is best for longevity up to age 65, after which a higher protein intake becomes more beneficial for health.

Utilize Fasting Mimicking Diet to preserve and increase lean body mass

Unlike GLP-1 agonists, multiple trials show that the Fasting Mimicking Diet does not cause lean body mass loss and can even increase it when combined with a healthy diet.

Avoid refeeding during chemotherapy to protect heart health

Refeeding while chemotherapy drugs are still high in your system is a very bad combination that can increase toxicity to the heart.

Implement periodic fasting to avoid 'thrifty mode' and enhance fat burning

Prolonged restriction can trigger a long-lasting, energy-saving 'thrifty mode,' making weight loss impossible, which is why periodic fasting is designed to switch to fat-burning without this negative effect.

Trigger cellular reprogramming through fasting

Fasting activates the body's innate ability to fix itself by turning on regenerative programs that reprogram cells, similar to how organs are first generated.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius