A Tiny Dose of this Mineral leads to a Massive Alzheimer’s Disease Reversing Effect

Physionic

Aug 25, 2025

Episode description

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0:00 - Introduction
0:11 - Brain Deficiency
0:44 - Plaques in the Brain
1:42 - Supplementation? Lithium Types?
3:52 - Dosing
4:15 - Main Points

References
[Study 508] Aron L, Ngian ZK, Qiu C, Choi J, Liang M, Drake DM, Hamplova SE, Lacey EK, Roche P, Yuan M, Hazaveh SS, Lee EA, Bennett DA, Yankner BA. Lithium deficiency and the onset of Alzheimer’s disease. Nature. 2025;628(8019):1-14. doi:10.1038/s41586-025-09335-x.

Funding/Conflicts: Mixed [Public: NIH / Non-Profit: The JPB Foundation, The Belfer Family Foundation, and The Cure Alzheimer’s Fund] // Potential Conflicts of Interest: B.A.Y. (Bruce A. Yankner) and L.A. (Liviu Aron) are inventors on a pending patent application related to lithium orotate and its therapeutic potential in Alzheimer’s disease. The other authors declared no competing interests
[A] Nunes MA, Viel TA, Buck HS. Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease. Curr Alzheimer Res. 2013;10(1):104-107. doi:10.2174/1567205011310010014

********CRITIQUES, RULES, AND NOTES********

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Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

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If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

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Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#alzheimersprevention #dementiatreatment #dementiasupport

Episode description

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*
Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2

*HEALTH AUTONOMY [COURSE]*
Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy

*JOIN THE COMMUNITY*
Join my Community [It’s Free!]: https://bit.ly/PhysionicCommunity2

*EMAIL LIST*
1-2 Weekly Email of Value [It’s Free!]: http://bit.ly/2AXIzK6

*HIRE ME FOR CONSULTING:*
Consulting: https://bit.ly/3dmUl2H

Created with Biorender

0:00 - Introduction
0:11 - Brain Deficiency
0:44 - Plaques in the Brain
1:42 - Supplementation? Lithium Types?
3:52 - Dosing
4:15 - Main Points

References
[Study 508] Aron L, Ngian ZK, Qiu C, Choi J, Liang M, Drake DM, Hamplova SE, Lacey EK, Roche P, Yuan M, Hazaveh SS, Lee EA, Bennett DA, Yankner BA. Lithium deficiency and the onset of Alzheimer’s disease. Nature. 2025;628(8019):1-14. doi:10.1038/s41586-025-09335-x.

Funding/Conflicts: Mixed [Public: NIH / Non-Profit: The JPB Foundation, The Belfer Family Foundation, and The Cure Alzheimer’s Fund] // Potential Conflicts of Interest: B.A.Y. (Bruce A. Yankner) and L.A. (Liviu Aron) are inventors on a pending patent application related to lithium orotate and its therapeutic potential in Alzheimer’s disease. The other authors declared no competing interests
[A] Nunes MA, Viel TA, Buck HS. Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease. Curr Alzheimer Res. 2013;10(1):104-107. doi:10.2174/1567205011310010014

********CRITIQUES, RULES, AND NOTES********

Be aware of the following rules before posting comments:
- Please do not post summaries of the video in the comments - it damages retention on the video and YouTube is less likely to promote it (these videos cost me a lot of money to produce).

Critiques of my work are welcome! Please be aware of the following notes & rules before submitting critique:

Be mindful that this content is not all encompassing on the subject at hand and is self-limited for brevity to reach a wider audience. Also, be aware that I receive hundreds of YouTube comments per day, so the only way your critique can be considered is if you follow the steps outlined below. Finally, YouTube auto-deletes links, so I do not see most comments with links attached.

RULES:
If your comment is rude, you will be banned.
If your comment is not about the studies/topics at hand (i.e. extending to other outcomes not discussed) or offers critique with no scientific basis, it is unlikely to receive a response.

If you can follow these rules, I will try to address your critique and if there is merit, I will add an AMENDMENT to the content in question and pin it so everyone can see it (thank you!).

Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

Disclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

#alzheimersprevention #dementiatreatment #dementiasupport

Mindsip insights from this episode:

Choose organic lithium salts for better Alzheimer's treatment

Mechanistic data suggests organic lithium salts are more effective against Alzheimer's-related brain degradation than inorganic forms like lithium chloride or carbonate.

Utilize microdoses to protect brain health

The dosage for preventing cognitive decline is on the microgram scale, which is a 1000-fold lower than the high doses used to treat bipolar disorder.

Utilize trace doses of lithium for cognitive enhancement

Human studies exploring cognitive benefits have used trace doses of lithium, typically around 300 to 400 micrograms.

Investigate low brain lithium levels to understand Alzheimer's risk

New research has identified a direct relationship between low lithium levels in the brain and the presence of neurodegenerative conditions like Alzheimer's disease.

Address lithium deficiency to reduce brain plaques in Alzheimer's

In mouse models of Alzheimer's, being deficient in the mineral lithium was shown to increase the amount of disruptive protein plaques in the brain.

Investigate lithium sequestration by amyloid plaques in brain cells

A leading theory suggests that available lithium gets sequestered by the amyloid plaques themselves, making it unavailable for use by brain cells.

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