Age Reversing Antibody Therapy: A Remarkable Breakthrough

Physionic

Aug 14, 2024

Episode description

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References [Copy & Paste DOI into Search Engine]
[1] doi:10.1038/s41586-024-07238-x
[2] doi:10.1038/d41586-024-00680-x

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#agereversal #immunotherapy #agingbackwards

Episode description

Mindsip insights from this episode:

Balance immune system to combat aging effects

As we age, the ratio of generalized myeloid immune cells to specific lymphoid cells increases, leading to chronic inflammation and a reduced ability to fight persistent pathogens.

#aging

#immune-system

Target specific aging stem cells to address immune imbalance

Researchers identified surface proteins, like CD150, that are highly expressed on the specific stem cells that cause the age-related myeloid-dominant immune imbalance.

#aging

#stem-cell

Rejuvenate immune cells with antibody cocktail

By injecting old mice with antibodies that target these specific myeloid-biased stem cells, researchers successfully reduced their numbers and made the overall immune profile more youthful.

#immune-system

#stem-cell

Enable cell cannibalism to promote cellular renewal

The treatment works partly by blocking a 'don't eat me' signal called CD47 on the target cells, which allows other immune cells to consume and clear them via phagocytosis.

#cells

#regeneration

Restore vaccine effectiveness in aged mice with antibody treatment

Functionally, the antibody treatment restored the effectiveness of a vaccine in aged mice, preventing their spleens from enlarging after infection.

#immune-system

#vaccine

Leverage long-lasting antibody therapy for extended immunity

This antibody therapy is long-lasting, potentially boosting immunity for weeks or even months from a single treatment rather than requiring daily intervention.

#immune-system

#therapy

Eliminate myeloid-biased stem cells to reduce cancer risk

Eliminating these myeloid-biased stem cells could also lower cancer risk, as these cells may have gene profiles that predispose them to becoming cancerous.