AMA #58: Iron: its role in health, testing methods, and strategies for preventing and managing iron deficiency
Peter Attia
Apr 8, 2024
Mindsip insights from this episode:
Bind iron to transferrin to prevent toxicity
Although iron is water-soluble, it cannot travel freely in the plasma because it is highly toxic, requiring it to be bound to a transport protein called transferrin.
Recognize inflammation's role in masking iron deficiency
Ferritin is an acute phase reactant, meaning its levels can rise due to inflammation or infection, potentially masking an underlying iron deficiency on a blood test.
Request ferritin level tests for accurate iron assessment
You should specifically ask your doctor to test your ferritin levels, as a simple iron test is insufficient to understand your body's total iron stores.
Recognize iron's universal necessity for bodily function
It is difficult to find any tissue in the human body that does not require iron, underscoring its universal necessity for bodily function.
Recognize iron's critical role in genetics
A staggering 2% of the entire human genome is dedicated to encoding for iron-related proteins, highlighting its fundamental importance.
Recognize iron's critical role in health education
The host, a medical doctor, admits that the complexity of iron biology is a topic he only learned about recently, suggesting it's often overlooked in traditional medical training.
Maximize iron absorption beyond 10%
The body is surprisingly inefficient at absorbing dietary iron, typically taking in only about 10% of the 10-20 milligrams consumed daily.
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