AMA #71: Building strength and muscle mass: how to optimize training, nutrition, and more for longevity

Peter Attia

May 19, 2025

Episode description

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In this “Ask Me Anything” (AMA) episode, Peter dives deep into the topic of muscle mass and strength, examining their essential roles in both lifespan and healthspan. Drawing from over 30 hours of prior discussions with experts including Layne Norton, Andy Galpin, and Mike Israetel, this episode distills the most important insights into one comprehensive and up-to-date conversation. Peter explores why muscle matters for longevity, metabolic health, and injury prevention, and clarifies the differences between muscle mass and strength, including which is more vital for aging well. He breaks down practical strategies for building muscle safely and effectively, including progressive overload, training intensity, rep ranges, and the importance of explosive power. Peter also covers key nutrition strategies—like protein intake, timing, and creatine supplementation—and offers practical advice for everyone from beginners to seasoned lifters on building and maintaining muscle safely and sustainably.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #71 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

  • Peter’s humorous experience talking nutrition with a second grader [2:30];

  • Overview of topics, episode structure, and reasoning for focus on muscle mass and strength [6:00];

  • Defining key terms: muscle mass, strength, hypertrophy, power, and more [8:15];

  • The importance of muscular strength, muscle mass, and cardiorespiratory fitness for longevity [10:30];

  • Grip strength as a simple yet powerful predictor of all-cause mortality [

Episode description

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

In this “Ask Me Anything” (AMA) episode, Peter dives deep into the topic of muscle mass and strength, examining their essential roles in both lifespan and healthspan. Drawing from over 30 hours of prior discussions with experts including Layne Norton, Andy Galpin, and Mike Israetel, this episode distills the most important insights into one comprehensive and up-to-date conversation. Peter explores why muscle matters for longevity, metabolic health, and injury prevention, and clarifies the differences between muscle mass and strength, including which is more vital for aging well. He breaks down practical strategies for building muscle safely and effectively, including progressive overload, training intensity, rep ranges, and the importance of explosive power. Peter also covers key nutrition strategies—like protein intake, timing, and creatine supplementation—and offers practical advice for everyone from beginners to seasoned lifters on building and maintaining muscle safely and sustainably.

If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #71 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.

We discuss:

  • Peter’s humorous experience talking nutrition with a second grader [2:30];

  • Overview of topics, episode structure, and reasoning for focus on muscle mass and strength [6:00];

  • Defining key terms: muscle mass, strength, hypertrophy, power, and more [8:15];

  • The importance of muscular strength, muscle mass, and cardiorespiratory fitness for longevity [10:30];

  • Grip strength as a simple yet powerful predictor of all-cause mortality [

Mindsip insights from this episode:

Implement progressive overload and nutrition for effective muscle building

For longevity, an effective muscle-building program should incorporate progressive overload, power training, and nutritional support like creatine.

Build muscle mass and strength to enhance lifespan and healthspan

Muscle mass and strength are considered central pillars for both extending lifespan and improving healthspan.

Reflect on children's insights about sweeteners and health risks

Peter Attia was told by a 7-year-old that his diet soda causes cancer, but was impressed when the child added that the dose was too small to be quickly fatal.

Incorporate power training and explosive movements into aging routine

Explosive movements and power training are particularly important as we age and should be integrated into a routine.

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© Mindsip 2025 – Made with ❤ in Vilnius