Butter linked to Cancer: Large Studies Reveal the Hidden Cost

Physionic

Nov 3, 2025

Episode description

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Butter on Cancer - Mechanism Video: https://youtu.be/G4eWcMVXe48?si=2Qrs31JNDhAnGXnl

0:00 - Introduction
0:55 - Butter, Cancer, Mortality, Oh My!
10:12 - Main Points/ Key Takeaways

References
[Study 536] Zhang Y, Chadaideh KS, Li Y, et al. Butter and Plant-Based Oils Intake and Mortality. JAMA Intern Med. 2025;185(5):549-560. doi:10.1001/jamainternmed.2025.0205. Published online March 6, 2025.

Funding/Conflicts: Public Funding [Supported by NIH grants (UM1 CA186107, P01 CA87969, R01 HL034594, R01 HL088521, U01 CA176726, U01 HL145386, U01 CA167552, R01 HL35464, R01 HL60712, P30 DK46200, R00 DK119412, R01 AG077489, R01 NR019992); the NIH had no role in study design, data collection/management/analysis, interpretation, manuscript preparation/approval, or the decision to submit; conflicts: Drs Willett and Stampfer reported NIH grants during the conduct of the study.]; Non-profit funding [No non-profit funders are listed as supporting this study; conflicts: Dr Guasch-Ferré reported grants from the Novo Nordisk Foundation (outside the submitted work).]; Industry funding [No industry funders are listed as supporting this study; conflicts: Dr Guasch-Ferré reported grants from the International Nut and Dried Fruit Council (outside the submitted work); no other disclosures were reported.]

[A] Zhang Y, Zhuang P, Wu F, He W, Mao L, Jia W, et al. Cooking oil/fat consumption and deaths from cardiometabolic diseases and other causes: prospective analysis of 521,120 individuals. BMC Med. 2021;19(1):92. doi:10.1186/s12916-021-01961-2.

[B] Jin S, Je Y. Dairy Consumption and Total Cancer and Cancer-Specific Mortality: A Meta-Analysis of Prospective Cohort Studies. Adv Nutr. 2022;13(4):1063-1082. doi:10.1093/advances/nmab135

[C] Lu W, Chen H, Niu Y, Wu H, Xia D, Wu Y. Dairy products intake and cancer mortality risk: a meta-analysis of 11 population-based cohort studies. Nutr J. 2016;15(1):91. Published 2016 Oct 21. doi:10.1186/s12937-016-0210-9

[D] Kunkemoeller B, Prendeville H, McIntyre C, et al. The source of dietary fat influences anti-tumour immunity in obese mice. Nat Metab. 2025;7(8):1630-1645. doi:10.1038/s42255-025-01330-w

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Mindsip insights from this episode:

Limit butter consumption to reduce cancer mortality risk

A 33-year study of over 200,000 people found that the highest butter consumption was linked to an estimated 12% increased risk of dying from cancer.

#cancer

#nutrition

Limit butter consumption to reduce mortality risk

Even after researchers adjusted for refined bread consumption, the statistical link between adding butter to food and mortality remained.

#mortality

#nutrition

Use butter wisely to manage mortality risk

Using butter for baking and frying was not associated with increased mortality risk, whereas adding butter directly to food like bread was.

#nutrition

#risk

Eliminate trans fats from butter category for accurate health insights

The study's 'total butter' category was contaminated with margarine blends, which contained harmful trans fats during the early data collection period.

#nutrition

#trans-fat

Recognize ketogenic diets as unique physiological contexts

These findings on butter do not apply to ketogenic diets, as being in a ketogenic state is an objectively different physiological context.

#keto

#metabolism

Address butter's cancer risk in overweight individuals

The negative effects of butter on cancer may be a bigger problem in an 'obesogenic environment,' meaning for overweight individuals.

#cancer

#obesity

Understand butter's role in cancer mortality, not occurrence

The data links butter to cancer mortality (dying from it), not cancer occurrence (getting it), suggesting it may only be a detriment once cancer is already present.