Control Sugar Cravings & Metabolism with Science-Based Tools | Huberman Lab Essentials

Andrew Huberman

Apr 30, 2026

Episode description

In this Huberman Lab Essentials episode, I explain how the body senses and uses sugar, and why understanding those mechanisms can help reduce sugar cravings. I discuss different types of sugar and how they are processed by pathways in the gut and the brain to shape appetite and the desire for specific foods. I also share many science-based tools to help curb sugar cravings and support healthy blood sugar regulation.

Show notes: https://go.hubermanlab.com/VAHQhla

Watch more Huberman Lab Essentials: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S&si=a1_sA7rUT-fE0OM5

Huberman Lab
Instagram: https://www.instagram.com/hubermanlab
Threads: https://www.threads.net/@hubermanlab
X: https://x.com/hubermanlab
Facebook: https://www.facebook.com/hubermanlab
TikTok: https://www.tiktok.com/@hubermanlab
LinkedIn: https://www.linkedin.com/in/andrew-huberman
Website: https://www.hubermanlab.com
Newsletter: https://www.hubermanlab.com/newsletter

Timestamps
00:00:00 Sugar
00:00:37 Hunger, Hormones & Blood Glucose
00:03:03 Fructose vs Glucose, Controlling Hunger
00:06:30 Brain Circuits: Sweet Taste & Nutritive Pathways
00:09:27 Sweet Taste & Dopamine
00:11:58 Gut & Blood Glucose; Tool: Sugar Cravings & Hidden Sugars
00:14:20 Glycemic Index, Tool: Food Choices, Fiber & Sugar Intake
00:18:22 Glutamine Supplementation, Leaky Gut & Sugar Cravings
00:20:44 Tools: Lemon Juice & Cinnamon to Blunt Blood Glucose
00:25:05 Berberine & Potent Molecules to Regulate Blood Glucose
00:26:47 Tool: Quality Sleep & Sugar Cravings

#hubermanlab #health #science

Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer

Mindsip insights from this episode:

Combine fiber or fat with sugar to stabilize blood glucose levels

Ingesting fiber or fat along with a sugary food can reduce its glycemic index, blunting the blood glucose spike and the subsequent dopamine release.

Leverage gut neurons to understand sugar cravings

Specialized 'neuropod cells' in your gut detect sugar and trigger dopamine release in your brain, driving cravings even without you consciously tasting sweetness.

Improve sleep quality to regulate sugar metabolism

Different stages of sleep are associated with specific metabolic patterns, and poor sleep quality can disrupt sugar metabolism and increase cravings for sugary foods.

Ingest lemon juice to blunt blood glucose spikes

Ingesting a couple of tablespoons of lemon or lime juice before, during, or after a meal can help blunt the blood glucose response.

Use glutamine to curb sugar cravings without calories

Supplementing with the amino acid glutamine may blunt sugar cravings by activating the same gut-to-brain dopamine pathways that sugar does, but without the calories.

Use berberine safely to lower blood glucose without side effects

Berberine is a powerful supplement that can dramatically lower blood glucose, but taking it on an empty stomach can cause hypoglycemia with severe side effects like headaches and dizziness.

Understand brain's dual pathways for sugar cravings

Your brain has one hardwired pathway for the conscious taste of sweetness and a separate, parallel pathway that craves the nutritive, glucose-raising component of sugar.

Limit fructose intake to control hunger signals

Ingesting fructose shifts your hormone system to make you feel hungrier, regardless of the calories you've consumed, by suppressing the hormones that normally reduce hunger.

Understand sugar's dopamine effect to curb cravings

The dopamine released from eating sugar doesn't create a feeling of satisfaction, but rather produces the sensation of wanting more of that food.

DOWNLOAD THE APP

Unlock the wisdom of longevity

DOWNLOAD THE APP

Unlock the wisdom of longevity

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius

Unlock the wisdom of longevity

© Mindsip 2025 – Made with ❤ in Vilnius